PRIMARY STRUCTURE OF RAT MONOAMINE-OXIDASE A DEDUCED FROM CDNA AND ITS EXPRESSION IN RAT-TISSUES

被引：51

作者：

KUWAHARA, T ^{[1
]}

TAKAMOTO, S ^{[1
]}

ITO, A ^{[1
]}

机构：

[1] KYUSHU UNIV,FAC SCI,DEPT BIOL,FUKUOKA 812,JAPAN

来源：

AGRICULTURAL AND BIOLOGICAL CHEMISTRY | 1990年 / 54卷 / 01期

关键词：

D O I：

10.1080/00021369.1990.10869903

中图分类号：

S3 [农学（农艺学）];

学科分类号：

0901 ;

摘要：

The cDNA for rat monoamine oxidase A (MAO-A) mRNA was isolated from a liver cDNA library in λ gt11 as the cDNA species cross-hybridizing with rat monoamine oxidase B (MAO-B) cDNA. The primary structure of the protein, deduced from the nucleotide sequence, consisted of 526 amino acid residues and its molecular mass was·calculated to be 59.6 kD. The amino acid sequence shows about 70% identity with that of rat MAO-B. Northern blot analysis showed that MAO-A mRNA was expressed in various rat tissues and the highest expression was observed in heart. The MAO-B mRNA was quite different from MAO-A mRNA in the tissue-specific expression and liver had the highest level of the mRNA. © 1990 by the Japan Society for Bioscience, Biotechnology, and Agrochemistry. All rights reserved.

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页码：253 / 257

页数：5

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