ASSOCIATION OF TYROSINE HYDROXYLASE WITH SYNAPTIC VESICLES IN BOVINE CAUDATE NUCLEUS

被引：38

作者：

FAHN, S

RODMAN, JS

COTE, LJ

机构：

[1] Department of Neurology, Columbia University, College of Physicians and Surgeons, New York, New York

来源：

JOURNAL OF NEUROCHEMISTRY | 1969年 / 16卷 / 09期

关键词：

D O I：

10.1111/j.1471-4159.1969.tb05979.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract— The subcellular distribution of tyrosine hydroxylase in the bovine caudate nucleus was investigated, with five other enzymes serving as biochemical markers, and coordinated with electron microscopic observations. Tyrosine hydroxylase is particulate bound and has relatively high specific activities in the synaptosome‐enriched subfractions and in the synaptic vesicle fraction. The association of tyrosine hydroxylase with the synaptic vesicles is consistent with the theory of feedback regulation of catecholamine synthesis. Copyright © 1969, Wiley Blackwell. All rights reserved

引用

页码：1293 / +

页数：1

共 36 条

[1] SODIUM-POTASSIUM-ACTIVATED ATPASE AND POTASSIUM-ACTIVATED P-NITROPHENYLPHOSPHATASE - A COMPARISON OF THEIR SUBCELLULAR LOCALIZATIONS IN RAT BRAIN [J].