CAFFEINE CONSUMPTION DECREASES THE RESPONSE TO BRONCHOPROVOCATION CHALLENGE WITH DRY GAS HYPERVENTILATION

被引:27
作者
DUFFY, P [1 ]
PHILLIPS, YY [1 ]
机构
[1] WALTER REED ARMY MED CTR, DEPT MED, WASHINGTON, DC 20307 USA
关键词
D O I
10.1378/chest.99.6.1374
中图分类号
R4 [临床医学];
学科分类号
1002 [临床医学]; 100602 [中西医结合临床];
摘要
Objective: To determine whether caffeine consumption affects bronchoprovocation challenge (BPC). Design: A prospective, double-blind, placebo-controlled, randomized, crossover trial. Patients: Eleven nonsmoking men, aged 18 to 42 years, with normal baseline spirometry and evidence of exercise-induced bronchospasm. Intervention: On three separate test days, each individual received, in random order, either placebo, 5 mg/kg caffeine, or 10 mg/kg caffeine, and then underwent BPC with eucapnic voluntary hyperventilation (EVH). Results: Caffeine (10 mg/kg) significantly reduced bronchoconstriction compared to placebo (p = 0.02). The reduction in bronchoconstriction correlated with the serum level of caffeine (p = 0.014). Conclusions: Caffeine decreases bronchoconstriction due to EVH. Caffeine should be eliminated from diet prior to BPC.
引用
收藏
页码:1374 / 1377
页数:4
相关论文
共 30 条
[1]
[Anonymous], 1987, Am Rev Respir Dis, V136, P1285
[2]
COMPARISON OF AIRWAY REACTIVITY INDUCED BY HISTAMINE, METHACHOLINE, AND ISOCAPNIC HYPERVENTILATION IN NORMAL AND ASTHMATIC SUBJECTS [J].
AQUILINA, AT .
THORAX, 1983, 38 (10) :766-770
[3]
THE BRONCHODILATOR EFFECTS AND PHARMACOKINETICS OF CAFFEINE IN ASTHMA [J].
BECKER, AB ;
SIMONS, KJ ;
GILLESPIE, CA ;
SIMONS, FER .
NEW ENGLAND JOURNAL OF MEDICINE, 1984, 310 (12) :743-746
[4]
BUKOWSKYJ M, 1987, AM REV RESPIR DIS, V135, P173
[5]
THEOPHYLLINE PARTIALLY INHIBITS BRONCHOCONSTRICTION CAUSED BY INHALED HISTAMINE IN SUBJECTS WITH ASTHMA [J].
CARTIER, A ;
LEMIRE, I ;
LARCHEVEQUE, J ;
GHEZZO, H ;
MARTIN, RR ;
MALO, JL .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1986, 77 (04) :570-575
[6]
CHUNG KF, 1989, EUR RESPIR J, V2, P763
[7]
THEOPHYLLINE DOES NOT INHIBIT ALLERGEN-INDUCED INCREASE IN AIRWAY RESPONSIVENESS TO METHACHOLINE [J].
COCKCROFT, DW ;
MURDOCK, KY ;
GORE, BP ;
OBYRNE, PM ;
MANNING, P .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1989, 83 (05) :913-920
[8]
EFFECT OF DIETARY CAFFEINE ON AIRWAY REACTIVITY IN ASTHMA [J].
CRIVELLI, M ;
WAHLLANDER, A ;
JOST, G ;
PREISIG, R ;
BACHOFEN, H .
RESPIRATION, 1986, 50 (04) :258-264
[9]
CROPP GJA, 1980, ATS NEWS SPR, P11
[10]
DEAL EC, 1980, AM REV RESPIR DIS, V121, P621