PREMEDICATION OF CHILDREN WITH ORAL MIDAZOLAM

被引:125
作者
MCMILLAN, CO
SPAHRSCHOPFER, IA
SIKICH, N
HARTLEY, E
LERMAN, J
机构
[1] UNIV TORONTO,HOSP SICK CHILDREN,DEPT ANAESTHESIA,555 UNIV AVE,TORONTO M5G 1X8,ONTARIO,CANADA
[2] UNIV TORONTO,HOSP SICK CHILDREN,RES INST,TORONTO M5G 1X8,ONTARIO,CANADA
来源
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE | 1992年 / 39卷 / 06期
关键词
ANESTHESIA; OUTPATIENT; PEDIATRIC; ANESTHETICS; INTRAVENOUS; MIDAZOLAM; PREMEDICATION;
D O I
10.1007/BF03008315
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
In a randomized, double-blind, placebo-controlled study, the safety, efficacy and feasibility of oral midazolam premedication in children were evaluated in an ambulatory surgery unit. Eighty unmedicated children (ASA PS I or II, ages 1-6 yr) were randomly assigned to one of four groups receiving midazolam 0.5, 0.75, or 1.0 mg . kg-1 or a placebo 30 min before separation from parents. Heart rate, systolic blood pressure, arterial oxygen saturation, respiratory rate, sedation and anxiolysis scores were recorded before premedication, every five minutes for 30 min and then during induction of anaesthesia and recovery. We found that heart rate, systolic blood pressure, arterial oxygen saturation and respiratory rate were unchanged during the study. Sedation and anxiolysis scores in the midazolam-treated groups were greater than those in the placebo group and that anxiolysis at the time of separation from the parents was judged excellent in 80-90% of the children who received midazolam. However, sedation and anxiolysis did not differ among the three midazolam groups. Mean times to discharge from hospital were similar for all four groups. The side effects, loss of balance and head control, blurred vision and dysphoric reactions were observed only in the 0.75 and 1.0 mg . kg-1 midazolam groups. We conclude that oral midazolam 0. 5 mg . kg-1 is a safe and effective premedication and that 0. 75 and 1 mg . kg-1 while offering no additional benefit, may cause more side effects.
引用
收藏
页码:545 / 550
页数:6
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