TRANSFER OF CD8+ T-CELLS INTO SCID MICE AND ACTIVATION OF MEMORY VIRUS-SPECIFIC CYTOTOXIC T-CELLS

被引:5
作者
KOS, FJ [1 ]
MULLBACHER, A [1 ]
机构
[1] AUSTRALIAN NATL UNIV, JOHN CURTIN SCH MED RES, DIV CELL BIOL, POB 334, CANBERRA, ACT 2601, AUSTRALIA
关键词
D O I
10.1111/j.1365-3083.1993.tb03329.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The requirements for the activation of naive and memory CD8+ cytotoxic T (Tc) cells into effector virus-specific Tc cells after transferring them into SCID mice were investigated. SCID mice reconstituted with splenocytes or purified CD8+ T cells from naive or influenza-immune syngeneic mice and immunized with influenza virus generated effector Tc cells specific for influenza virus-infected target cells in vitro. The kinetics of the response varied between those two populations. The generation of effector Tc cells after transfer of memory CD8+ T cells indicates that there exists no absolute requirement for 'help' in the activation of memory virus-immune Tc cells. However, under the conditions described here the in vitro immunogenic peptide NPP derived from influenza nucleoprotein is not sufficient to elicit a response in vivo.
引用
收藏
页码:523 / 528
页数:6
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