SYNTHESIS OF DIAMINODIDEOXYALDITOL ANALOGS OF CISPLATIN AS ANTITUMOR AGENTS

被引：26

作者：

HANESSIAN, S

GAUTHIER, JY

OKAMOTO, K

BEAUCHAMP, AL

THEOPHANIDES, T

机构：

[1] Department of Chemistry, University of Montreal, Montreal

来源：

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE | 1993年 / 71卷 / 06期

关键词：

D O I：

10.1139/v93-117

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Acyclic vicinal polyol complexes related to cisplatin were synthesized from D-mannitol by stereocontrolled manipulation of the hydroxy groups. Controlled cleavage of a 3,4-diazido hexitol gave the corresponding D-threitol and D-Xylitol analogs, which were converted to their diamino platinum complexes. The antitumor activity of these compounds is reported.

引用

页码：880 / 885

页数：6

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