SYNTHESIS OF DIAMINODIDEOXYALDITOL ANALOGS OF CISPLATIN AS ANTITUMOR AGENTS

被引:26
作者
HANESSIAN, S
GAUTHIER, JY
OKAMOTO, K
BEAUCHAMP, AL
THEOPHANIDES, T
机构
[1] Department of Chemistry, University of Montreal, Montreal
来源
CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE | 1993年 / 71卷 / 06期
关键词
D O I
10.1139/v93-117
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Acyclic vicinal polyol complexes related to cisplatin were synthesized from D-mannitol by stereocontrolled manipulation of the hydroxy groups. Controlled cleavage of a 3,4-diazido hexitol gave the corresponding D-threitol and D-Xylitol analogs, which were converted to their diamino platinum complexes. The antitumor activity of these compounds is reported.
引用
收藏
页码:880 / 885
页数:6
相关论文
共 32 条
[21]   AN FT-IR AND H-1-NMR SPECTRAL STUDY OF SUGAR RING CONFORMATIONS IN GUANOSINE AND IN SEVERAL PLATINUM-(II) COMPLEXES [J].
OKAMOTO, K ;
BEHNAM, V ;
GAUTHIER, JY ;
HANESSIAN, S ;
THEOPHANIDES, T .
INORGANICA CHIMICA ACTA-BIOINORGANIC CHEMISTRY, 1986, 123 (01) :L1-L2
[22]   FT-IR AND H-1-NMR SPECTROSCOPIC STUDIES OF C2'-ENDO, C3'-ENDO SUGAR RING CONFORMATIONS IN 5'-GMP AND 3'-GMP NUCLEOTIDES AND THEIR PLATINUM COMPLEXES [J].
OKAMOTO, K ;
BEHNAM, V ;
VIET, MTP ;
POLISSIOU, M ;
GAUTHIER, JY ;
HANESSIAN, S ;
THEOPHANIDES, T .
INORGANICA CHIMICA ACTA-BIOINORGANIC CHEMISTRY, 1986, 123 (01) :L3-L5
[23]   NEW CISPLATIN ANALOGS - ON THE WAY TO BETTER ANTITUMOR AGENTS [J].
PASINI, A ;
ZUNINO, F .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1987, 26 (07) :615-624
[24]  
Roberts J J, 1979, Prog Nucleic Acid Res Mol Biol, V22, P71, DOI 10.1016/S0079-6603(08)60799-0
[25]  
Roberts J.J., 1983, MOL ASPECTS ANTICANC, P183
[26]  
ROSENBERG B, 1969, NATURE, P222
[27]   COHERENT X-RAY SCATTERING FOR HYDROGEN ATOM IN HYDROGEN MOLECULE [J].
STEWART, RF ;
DAVIDSON, ER ;
SIMPSON, WT .
JOURNAL OF CHEMICAL PHYSICS, 1965, 42 (09) :3175-&
[28]   RAPID CHROMATOGRAPHIC TECHNIQUE FOR PREPARATIVE SEPARATIONS WITH MODERATE RESOLUTION [J].
STILL, WC ;
KAHN, M ;
MITRA, A .
JOURNAL OF ORGANIC CHEMISTRY, 1978, 43 (14) :2923-2925
[29]   HIGHLY-ACTIVE ANTITUMOR PLATINUM(II) COMPLEXES OF AMINO-SUGARS [J].
TSUBOMURA, T ;
OGAWA, M ;
YANO, S ;
KOBAYASHI, K ;
SAKURAI, T ;
YOSHIKAWA, S .
INORGANIC CHEMISTRY, 1990, 29 (14) :2622-2626
[30]  
VERMORKEN JB, 1982, NETH J MED, V25, P270