BOTULINUM-B TOXIN AS AN ALTERNATIVE TO BOTULINUM-A TOXIN - A HISTOLOGIC-STUDY

被引：15

作者：

BORODIC, GE ^{[1
]}

PEARCE, LB ^{[1
]}

SMITH, KL ^{[1
]}

PHELAN, M ^{[1
]}

FERRANTE, R ^{[1
]}

机构：

[1] BOSTON UNIV HOSP,SCH MED,BOSTON,MA 02218

来源：

OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY | 1993年 / 9卷 / 03期

关键词：

MOVEMENT DISORDERS; BOTULINUM-B TOXIN; BOTULINUM-A TOXIN; ANIMAL STUDIES; BLEPHAROSPASM;

D O I：

10.1097/00002341-199309000-00003

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Histochemical effects of botulinum B toxin were studied on fibers from longissimus dorsi muscle in Albino rabbits and compared to effects produced by botulinum A toxin. Acetylcholinesterase staining, muscle fiber size analysis, and ATPase staining indicated botulinum B toxin produced a denervation gradient and field similar to that produced by botulinum A toxin. At 5 weeks postinjection with botulinum B toxin, analysis showed muscle fiber size variability, and diffuse acetylcholinesterase fiber staining comparable to botulinum A toxin at the injection site. Muscle sections taken at 4.0 cm for analysis showed statistically significant decreased fiber size variability and contraction of acetylcholinesterase staining pattern for both immunotypes. In addition, the denervation reflected by histochemical staining and fiber size analysis appeared transient and lasted for approximately 3 months for both immunotypes. These findings suggest botulinum B toxin produces pharmacologic effects on innervation of striated muscle similar to botulinum A toxin. Because immunologic tolerance has been demonstrated after therapeutic botulinum A toxin injections, further clinical studies need to be conducted with other immunotypes of toxin with no cross-reactivity to type A.

引用

页码：182 / 190

页数：9

共 43 条

[1] Scott A.B., Kennedy E.G., Stubbs H.A., Botulinum A., Toxin injection as a treatment for blepharospasm, Arch Ophthalmol, 103, pp. 347-350, (1985)
[2] Elston J., Russell R., Effect of treatment with botu-linum on neurogenic blepharospasm, Br Med J, 290, pp. 1857-1859, (1985)
[3] Dutton J.J., Buckley E.G., Botulinum toxin in the management of blepharospasm, Arch Neurol, 43, pp. 380-382, (1986)
[4] Borodic G.E., Cozzolino D., Blepharospasm and its treatment, with emphasis on the use of botulinum toxin, Plast Reconstr Surg, 83, pp. 546-554, (1989)
[5] Borodic G.E., Cozzolino D., Townsend D.J., Dose-response relationships in patients treated with botulinum toxin for more than three years (Abstract). Sixth International Meeting of the Benign Essential Blepharospasm Research Foundation: 1988 Aug 25-27
[6] Cambridge, MA, Ear Nose Throat J, 67, (1988)
[7] Jankovic J., Orman J., Botulinum toxin for cranial cervical dystonia: A double blind placebo controlled study, Neurology, 37, pp. 616-623, (1987)
[8] Gelb D.J., Lowenstein D.H., Arminoff M.J., Controlled trial of botulinum toxin injections in the treatment of spasmodic torticollis, Neurology, 39, pp. 80-84, (1989)
[9] Fletcher N.A., Quinn N., Dystonic syndromes, Curr Opin Neurol Neurosurg, 2, pp. 330-333, (1989)
[10] Ludlow C.L., Naunton R.F., Fujita M., Sedory S.E., Spasmodic dysphonia botulinum injection after recurrent nerve surgery, Otolaryngol Head Neck Surg, 101, pp. 122-131, (1990)

← 1 2 3 4 5 →