NEW 1,2,4(H)-TRIAZOLE DERIVATIVES AS DIURETIC AGENTS

被引：60

作者：

SHAH, MH

MHASALKA.MY

PATKI, VM

DELIWALA, CV

SHETH, UK

机构：

[1] Department of Chemotherapy, Hafkine Institute, Bombay

[2] Departent of Pharmacology, Sheth G. S. Medical College, Bombay

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 11期

关键词：

Diuretic activity—l,2,4(H)‐triazole derivatives; Mercapto‐triazoles—synthesis; Structure‐activity relationship—triazole rings;

D O I：

10.1002/jps.2600581123

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Sixty‐three new 1,2,4(H)‐triazole derivatives have been prepared and their diuretic activity studied in rats. Sequential screening showed 14 compounds possessing significant diuretic activity. 3‐Phenyl‐4‐allyl‐5‐mercapto‐l,2,4(H)‐triazole and 3‐o‐chlorophenyl‐4‐allyl‐5‐mercapto‐1,2,4(H)‐triazole were the most potent compounds in the present series. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1398 / &

共 6 条

[1] The interaction of chlorine with different types of organic sulfur compounds [J].