SUPPRESSOR ADHERENT PHAGOCYTIC-CELLS IN SOLID TUMORS - POSTULATED ESCAPE MECHANISM

被引：3

作者：

PARKS, RC

机构：

[1] AMC Cancer Research Center and Hospital, Lakewood, CO 80214

来源：

MEDICAL HYPOTHESES | 1979年 / 5卷 / 09期

关键词：

adherent phagocytic cells; allogeneic tumor; anti-tumor immunity; coterminous; Graft-versus-host;

D O I：

10.1016/0306-9877(79)90050-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A localized graft vs. host reaction was used to assess cellular immunity of mice supporting progressive growth of an allogeneic tumor. Early in tumor development anti-tumor cellular-mediated immunity was hyper-responsive, and adherent phagocytic cells isolated from the neoplasm would inhibit specific immunological response. Based on these observations and indirect inference a major factor in success of an immunogenic tumor is apparently the coterminous development of a normal adherent phagocytic cell population which specifically nullifies, in situ, cellular-mediated anti-tumor immunity.

引用

页码：1017 / 1023

页数：7

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