BIOTRANSFORMATION OF 4-ANDROSTENE-3,17-DIONE BY GREEN CELL-SUSPENSION OF MARCHANTIA-POLYMORPHA - STEREOSELECTIVE REDUCTION AT CARBON-17

被引：12

作者：

HAMADA, H

KAWABE, S

机构：

[1] Department of Applied Science, Okayama University of Science, Okayama, 700

来源：

LIFE SCIENCES | 1991年 / 48卷 / 07期

关键词：

D O I：

10.1016/0024-3205(91)90535-J

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The biotransformation of 4-androstene-3, 17-dione by a green cell suspension of Marchantia polymorpha was studied. It was found that the cultured cells stereoselectively reduce the carbonyl group of 4-androstene-3, 17-dione from the re-face at C-17 to form testosterone as the primary metabolite.

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页码：613 / 615

页数：3

相关论文

共 9 条

[1] TRANSFORMATION OF STEROIDS BY ALGAE [J].

ABULHAJJ, YJ ;

QIAN, XD .

JOURNAL OF NATURAL PRODUCTS, 1986, 49 (02) :244-248

[2] ENANTIOSELECTIVITY IN THE BIOTRANSFORMATION OF MONOCYCLIC AND BICYCLIC MONOTERPENOIDS WITH THE CULTURED-CELLS OF NICOTIANA-TABACUM [J].

HAMADA, H .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1988, 61 (03) :869-878

[3]

HAMADA H, 1988, PLANT TISSUE CULTURE, V5, P34

[4]

Hawkins D.R., 1988, BIOTRANSFORMATIONS

[5] STUDIES ON PLANT-TISSUE CULTURES .22. BIOTRANSFORMATION OF TESTOSTERONE AND OTHER ANDROGENS BY SUSPENSION CULTURES OF NICOTIANA-TABACUM BRIGHT YELLOW [J].

HIROTANI, M ;

FURUYA, T .

PHYTOCHEMISTRY, 1974, 13 (10) :2135-2142

[6] ESTABLISHMENT AND GROWTH-CHARACTERISTICS OF A CELL-SUSPENSION CULTURE OF MARCHANTIA-POLYMORPHA L WITH HIGH CHLOROPHYLL CONTENT [J].

OHTA, Y ;

KATOH, K ;

MIYAKE, K .

PLANTA, 1977, 136 (03) :229-232

[7] CALLUS FORMATION IN LIVERWORT, MARCHANTIA-POLYMORPHA [J].

ONO, K .

JAPANESE JOURNAL OF GENETICS, 1973, 48 (01) :69-70

[8] MICROBIAL TRANSFORMATIONS OF STEROIDS .3. TRANSFORMATION OF PROGESTERONE BY SEPEDONIUM-AMPULLOSPORUM [J].

SMITH, KE ;

WHITE, KA ;

KIRK, DN .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1989, 33 (01) :81-87

[9] BIOTRANSFORMATION OF 3-OXO-PARA-MENTHANE DERIVATIVES BY CULTURED-CELLS OF NICOTIANA-TABACUM [J].

SUGA, T ;

HIRATA, T ;

HAMADA, H ;

MURAKAMI, S .

PHYTOCHEMISTRY, 1988, 27 (04) :1041-1044