BIOCHEMICAL EFFECTS OF LUXABENDAZOLE ON TRICHINELLA-SPIRALIS

被引：10

作者：

CRIADOFORNELIO, A

DEARMASSERRA, C

JIMENEZGONZALEZ, A

CASADOESCRIBANO, N

RODRIGUEZCAABEIRO, F

机构：

[1] Parasitology Laboratory, Parasitology and Microbiology Department, Faculty of Pharmacy, University of Alcalá de Henares, Madrid

来源：

PARASITOLOGY RESEARCH | 1990年 / 76卷 / 06期

关键词：

D O I：

10.1007/BF00931057

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Biochemical changes produced by luxabendazole in muscle-stage Trichinella spiralis larvae consisted of a decrease in free glucose and glycogen levels (46.71% and 35.66%, respectively) after in vivo treatment, slight in vitro inhibition of fumarate reductase activity (24.15%) and, finally, inhibition of [3H]-colchicine-tubulin binding, which was found to be of a competitive nature, with an inhibition constant (Ki) of 0.9×10-7M. In a parallel study, luxabendazole did not appear to be inhibitory to [3H]-colchicine binding to pig-brain tubulin. © 1990 Springer-Verlag.

引用

页码：518 / 520

页数：3

共 21 条

[1] ACTIVATION OF SUCCINATE-DEHYDROGENASE FROM ADULT FASCIOLA-HEPATICA (TREMATODA) [J].

BARRETT, J .

PARASITOLOGY, 1978, 76 (JUN) :269-275

[2]

BORGERS M, 1975, MICROTUBULES MICROTU, P497

[3]

BRYANT C, 1983, MOL BIOCHEM PARASIT, V7, P281, DOI 10.1016/0166-6851(83)90011-7

[4] SUCCINATE-DEHYDROGENASE AND FUMARATE REDUCTASE-ACTIVITY IN ASPICULURIS-TETRAPTERA AND ASCARIS-SUUM AND THE EFFECT OF THE ANTHELMINTICS CAMBENDAZOLE, THIABENDAZOLE, AND LEVAMISOLE [J].

COMLEY, JCW ;

WRIGHT, DJ .

INTERNATIONAL JOURNAL FOR PARASITOLOGY, 1981, 11 (01) :79-84

[5]

CORBA J, 1987, Helminthologia (Bratislava), V24, P227

[6]

DENOLLIN S, 1973, J PARASITOL, V59, P970, DOI 10.2307/3278626

[7] THE MODE OF ACTION OF SOME BENZIMIDAZOLE DRUGS ON TRICHINELLA-SPIRALIS [J].

FORNELIO, AC ;

CAABEIRO, FR ;

GONZALEZ, AJ .

PARASITOLOGY, 1987, 95 :61-70

[8] INTERACTION OF ANTHELMINTIC BENZIMIDAZOLES WITH ASCARIS-SUUM EMBRYONIC TUBULIN [J].

FRIEDMAN, PA ;

PLATZER, EG .

BIOCHIMICA ET BIOPHYSICA ACTA, 1980, 630 (02) :271-278

[9]

FRIEDMAN PA, 1980, BIOCHEM PHARMACOL, V28, P2680

[10]

GRZYWINSKI L, 1988, 7TH P INT C TRICH AL, P144

← 1 2 3 →