ADENOSINE DERIVED FROM HYDROLYSIS OF PRESYNAPTICALLY RELEASED ATP INHIBITS NEUROMUSCULAR-TRANSMISSION IN THE RAT

被引：24

作者：

SMITH, DO

LU, Z

机构：

[1] Department of Physiology, University of Wisconsin, Madison

来源：

NEUROSCIENCE LETTERS | 1991年 / 122卷 / 02期

关键词：

ATP; ADENOSINE; NEUROMUSCULAR TRANSMISSION;

D O I：

10.1016/0304-3940(91)90850-S

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It has been established that ATP is released from motor nerve terminals and that exogenous ATP depresses end-plate potential (e.p.p.) amplitudes. This study assessed whether presynaptically released ATP reduced e.p.p.s. E.p.p.s. in the rat extensor digitorum longus muscle were depressed by exogenous ATP and adenosine. If ATP hydrolysis to adenosine was blocked, however, ATP had no effect. Addition of theophylline increased e.p.p. amplitude due to removal of the depressant effect caused by ATP contained in the quantal release. This inhibition was absent when the rate of release was reduced by high Mg2+. It is concluded that e.p.p. inhibition is mediated by adenosine derived from presynaptically released ATP.

引用

页码：171 / 173

页数：3

共 10 条

[1] RELEASE OF ADENOSINE TRIPHOSPHATE FROM FROG SKELETAL MUSCLE IN VITRO [J].

BOYD, IA ;

FORRESTER, T .

JOURNAL OF PHYSIOLOGY-LONDON, 1968, 199 (01) :115-+

[2]

BURGER RM, 1970, J BIOL CHEM, V245, P6274

[3] EFFECT OF ADENOSINE ON RELEASE OF TRANSMITTER FROM PHRENIC NERVE OF RAT [J].

GINSBORG, BL ;

HIRST, GDS .

JOURNAL OF PHYSIOLOGY-LONDON, 1972, 224 (03) :629-&

[4] AUTORECEPTOR-MEDIATED PURINERGIC AND CHOLINERGIC INHIBITION OF MOTOR-NERVE TERMINAL CALCIUM CURRENTS IN THE RAT [J].

HAMILTON, BR ;

SMITH, DO .

JOURNAL OF PHYSIOLOGY-LONDON, 1991, 432 :327-341

[5] ON THE ROLE, INACTIVATION AND ORIGIN OF ENDOGENOUS ADENOSINE AT THE FROG NEUROMUSCULAR-JUNCTION [J].

RIBEIRO, JA ;

SEBASTIAO, AM .

JOURNAL OF PHYSIOLOGY-LONDON, 1987, 384 :571-585

[6] ASSOCIATION BETWEEN TRANSMITTER SECRETION AND RELEASE OF ADENINE-NUCLEOTIDES FROM MAMMALIAN MOTOR-NERVE TERMINALS [J].

SILINSKY, EM .

JOURNAL OF PHYSIOLOGY-LONDON, 1975, 247 (01) :145-162

[7] ON THE MECHANISM BY WHICH ADENOSINE RECEPTOR ACTIVATION INHIBITS THE RELEASE OF ACETYLCHOLINE FROM MOTOR-NERVE ENDINGS [J].

SILINSKY, EM .

JOURNAL OF PHYSIOLOGY-LONDON, 1984, 346 (JAN) :243-256

[8] EVIDENCE FOR SPECIFIC ADENOSINE RECEPTORS AT CHOLINERGIC NERVE-ENDINGS [J].

SILINSKY, EM .

BRITISH JOURNAL OF PHARMACOLOGY, 1980, 71 (01) :191-194

[9] ACETYLCHOLINE STORAGE, RELEASE AND LEAKAGE AT THE NEUROMUSCULAR-JUNCTION OF MATURE ADULT AND AGED RATS [J].

SMITH, DO .

JOURNAL OF PHYSIOLOGY-LONDON, 1984, 347 (FEB) :161-176

[10] SOURCES OF ADENOSINE RELEASED DURING NEUROMUSCULAR-TRANSMISSION IN THE RAT [J].

SMITH, DO .

JOURNAL OF PHYSIOLOGY-LONDON, 1991, 432 :343-354

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