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POTASSIUM CHANNELS IN AORTIC MICROSOMES - CONDUCTANCE, SELECTIVITY, BARIUM-INDUCED BLOCKAGE AND SUBCONDUCTANCE STATES

被引：8
作者：
BEZPROZVANNY, IB
BENEVOLENSKY, DS
NAUMOV, AP
机构：
[1] ACAD SCI USSR,INST CYTOL,LENINGRAD,USSR
[2] ACAD SCI USSR,INST EXPT CARDIOL,MOSCOW V-71,USSR
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1064卷 / 01期
关键词：
SARCOPLASMIC RETICULUM; BILAYER; POTASSIUM ION CHANNEL; BARIUM ION BLOCKAGE; CONDUCTANCE LEVEL; MICROSOME; (CANINE AORTA);
D O I：
10.1016/0005-2736(91)90413-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The activity of potassium channels of canine aortic sarcoplasmic reticulum was measured using the planar lipid bilayer-fusion technique. The channels have a conductance of 208 pS (400/100 mM K+ in cis/trans solutions) and potassium-to-sodium permeability ratio of 7.7. Ba2+ ions produced two main effects: one is the interruption of channel currents for tens to hundreds of milliseconds in a voltage-dependent manner, and the other is the appearance of a second conductance level with amplitude about 60% of the main level.
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页码：75 / 80
页数：6
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