EFFECT OF ENVIRONMENT ON CRYSTALLINITY AND CHEMICAL-STABILITY IN SOLID-STATE OF GROUND CEPHALOTIN SODIUM DURING STORAGE

Effects of environmental conditions on the crystallinity and the decomposition point (Dp) of ground cephalotin sodium during storage were investigated by X-ray diffraction and differential thermal analysis (DTA). The X-ray diffraction peaks of ground products increased after storage at 0% and 75% relative humidity (R.H.), at 35-degrees-C. The crystallinity of ground product increased at 75% R.H. and 0% R.H.,35-degrees-C, but that of ground product at 0% R.H., -30-degrees-C was not changed. The Dp measured by DTA of the ground product increased from 189.5-degrees-C to 197-degrees-C after 4 days at 75% R.H., but the Dp of the ground product at 0% R.H., -30-degrees-C for 4 days was 190.1-degrees-C. Relation between the Dp and the crystallinity of ground cefalotin sodium was a straight suggesting that the thermal stability of cefalotin sodium in the solid-state depends on the degree of crystallinity.