THE EFFECTS OF PARATHYROID-HORMONE ON L-TYPE VOLTAGE-DEPENDENT CALCIUM-CHANNEL CURRENTS IN VASCULAR SMOOTH-MUSCLE CELLS AND VENTRICULAR MYOCYTES ARE MEDIATED BY A CYCLIC-AMP DEPENDENT MECHANISM

被引：53

作者：

WANG, R ^{[1
]}

WU, LY ^{[1
]}

KARPINSKI, E ^{[1
]}

PANG, PKT ^{[1
]}

机构：

[1] UNIV ALBERTA,DEPT PHYSIOL,EDMONTON T6G 2H7,ALBERTA,CANADA

来源：

FEBS LETTERS | 1991年 / 282卷 / 02期

关键词：

CALCIUM CHANNEL; PARATHYROID HORMONE; CYCLIC AMP; VASCULAR SMOOTH MUSCLE CELL (RAT); VENTRICULAR MYOCYTE (RAT);

D O I：

10.1016/0014-5793(91)80507-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present study demonstrated that L channel currents were decreased in smooth muscle cells, and increased in ventricular myocytes by both bovine parathyroid hormone, (bPTH-(1-34)), and dibutyryl cyclic AMP (db-cAMP), using the whole cell version of the patch clamp technique with Ba2+ as the charge carrier. The effects of bPTH-(1-34) and db-cAMP on L channel currents were additive but not synergistic. Furthermore, the effects of bPTH-(1-34) on L channel currents in these 2 cells preparations were abolished in the presence of a cAMP antagonist. These results suggest that the effects of bPTH-(1-34) on channel currents in vascular smooth muscle cells and ventricular myocytes are mediated by a cAMP-dependent mechanism.

引用

页码：331 / 334

页数：4

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