QUANTITATION OF MEDULLARY ASTROGLIOSIS IN SUDDEN-INFANT-DEATH-SYNDROME

被引:22
作者
BRUCE, K [1 ]
BECKER, LE [1 ]
机构
[1] HOSP SICK CHILDREN, DEPT PATHOL, DIV NEUROPATHOL, 555 UNIV AVE, TORONTO M5G 1X8, ONTARIO, CANADA
关键词
ASTROGLIOSIS; SUDDEN INFANT DEATH SYNDROME; GLIAL FIBRILLARY ACIDIC PROTEIN; MEDULLA;
D O I
10.1159/000120571
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
One of the few relatively consistent pathologic observations in sudden infant death syndrome (SIDS) is astrogliosis of the brain stem. Astrogliosis is a nonspecific reactive process and its cause in SIDS, although still uncertain, is postulated to be hypoxia-ischemia. In this study, the distribution of reactive astrocytes throughout the rostral-caudal extent of the medulla has been determined. Although astrogliosis was present throughout the length of the medulla, it reached a maximum at levels 50-75% of total length, with 0% at the pontomedullary junction. Counting every reactive astrocyte through serial sections of the medulla seems unwarranted in view of the nonspecificity of the astrocytic response. This report proposes a practical approach to the quantitation of reactive astrocytes in SIDS by examining a representative sample of medulla midway through its length.
引用
收藏
页码:74 / 79
页数:6
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