SOLID-STATE ACETYLATION OF CODEINE PHOSPHATE BY ASPIRIN

被引：11

作者：

GALANTE, RN

VISALLI, AJ

PATEL, DM

机构：

[1] Analytical and Physical Chemistry Department, Research and Development, William R. Rorer, Inc., Fort Washington, Pennsylvania

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 12期

关键词：

Analgesics—aspirin; acetylation of codeine phosphate in solid dosage forms; pharmacokinetics; Antitussive agents—codeine phosphate; acetylation by aspirin in solid dosage forms; Aspirin—acetylation of codeine phosphate in solid dosage forms; GLC analysis of aspirin and salicylic acid; and codeine and acetylcodeine; Codeine phosphate—acetylation by aspirin; solid dosage forms;

D O I：

10.1002/jps.2600681208

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A nonsolvolytic (solid‐state) acetylation of codeine phosphate in the presence of aspirin to yield acetylcodeine phosphate is reported. GLC assays for the simultaneous determination of aspirin and salicylic acid and codeine and acetylcodeine are described. The apparent heat of activation for codeine phosphate is estimated, and the possible reaction mechanisms are discussed. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1494 / 1498

页数：5

共 21 条

[1] APPLICATION OF GAS-LIQUID-CHROMATOGRAPHY AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY TO ANALYSIS OF TRACE AMOUNTS OF SALICYLIC-ACID, ACETYLSALICYLIC ANHYDRIDE AND ACETYLSALICYLSALICYLIC ACID IN ASPIRIN SAMPLES AND ASPIRIN FORMULATIONS [J].

ALI, SL .

JOURNAL OF CHROMATOGRAPHY, 1976, 126 (NOV3) :651-663

[2] AUTOMATED HIGH-PRESSURE LIQUID-CHROMATOGRAPHIC ANALYSIS OF ASPIRIN, PHENACETIN, AND CAFFEINE [J].

ASCIONE, PP ;

CHREKIAN, GP .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1975, 64 (06) :1029-1033

[3]

BRUNSON MK, 1975, CLIN CHEM, V21, P1956

[4]

BUCKETT WR, 1963, J PHARM PHARMACOL, V16, P174

[5] DETERMINATION OF ASPIRIN BY GAS CHROMATOGRAPHY [J].

CRIPPEN, RC ;

FREIMUTH, HC .

ANALYTICAL CHEMISTRY, 1964, 36 (02) :273-&

[6] GAS CHROMATOGRAPHIC ANALYSIS OF ACETYLSALICYLIC ACID, PHENACETIN, CAFFEINE, AND CODEINE IN APC AND CODEINE TABLETS [J].

DECHENE, EB ;

BOOTH, LH ;

CAUGHEY, MJ .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1969, 21 (10) :678-&

[7]

Ebbighausen W O, 1973, Adv Biochem Psychopharmacol, V7, P135

[8] FORMATION OF ACETYLCODEINE FROM ASPIRIN AND CODEINE [J].

JACOBS, AL ;

DILATUSH, AE ;

WEINSTEI.S ;

WINDHEUS.JJ .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1966, 55 (09) :893-&

[9]

JAIN NC, 1975, CLIN CHEM, V21, P1486

[10] DIRECT ANALYSIS OF SALICYLIC-ACID IN KERATOLYTIC PLASTER BY GAS-SOLID CHROMATOGRAPHY [J].

KO, PH .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1977, 66 (05) :731-733

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