BEHAVIORAL EVIDENCE OF DEPOLARIZATION BLOCK OF MESENCEPHALIC DOPAMINE NEURONS BY ACUTE HALOPERIDOL IN PARTIALLY 6-HYDROXYDOPAMINE-LESIONED RATS

被引:8
作者
DOHERTY, M [1 ]
GRATTON, A [1 ]
机构
[1] MCGILL UNIV, DOUGLAS HOSP RES CTR, 6875 LASALLE BLVD, VERDUN H4H 1R3, QUEBEC, CANADA
关键词
D O I
10.1037/0735-7044.105.4.579
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The effects of acute haloperidol (HAL) and apomorphine (APO) administration were tested on the responsiveness of rats to medial forebrain bundle (MFB) brain stimulation reward (BSR) before and 28 days after partial dopamine (DA) depletion. Before 6-hydroxydopamine (6-OHDA) lesioning, HAL (50-100-mu-g/kg) and APO (25-mu-g/kg) both caused moderate decreases in the animals' responsiveness to BSR. In contrast, the same moderate doses of HAL completely abolished BSR after lesioning. However, postlesion responding for BSR after HAL could be reinstated by APO. The results of this study provide behavioral evidence that is consistent with recent electrophysiological data showing that acute HAL causes DA cells that survive 6-OHDA lesions to be driven into a state of depolarization block.
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页码:579 / 587
页数:9
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