OSTEOARTHROSIS INDUCED BY INTRAARTICULAR HYDROGEN-PEROXIDE INJECTION AND RUNNING LOAD

被引：29

作者：

KAIKI, G ^{[1
]}

TSUJI, H ^{[1
]}

YONEZAWA, T ^{[1
]}

SEKIDO, H ^{[1
]}

TAKANO, T ^{[1
]}

YAMASHITA, S ^{[1
]}

HIRANO, N ^{[1
]}

SANO, A ^{[1
]}

机构：

[1] TOYAMA MED & PHARMACEUT UNIV, DEPT ORTHOPAED SURG, SUGITANI, TOYAMA 93001, JAPAN

来源：

JOURNAL OF ORTHOPAEDIC RESEARCH | 1990年 / 8卷 / 05期

关键词：

Experimental osteoarthrosis; Hydrogen peroxide; Running load; Vitamin E;

D O I：

10.1002/jor.1100080515

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Osteoarthrosis of the rat knee joint was induced successfully by intra‐articular injection of 2% hydrogen peroxide (H2O2) and running load. In the group receiving two injections of physiological saline with running load, no histological osteoarthrotic knees were developed up to 8 weeks after the injection. In the group receiving two 2% H2O2 injections and running load, advanced osteoarthrosis occurred in all knees 8 weeks after the first injection, and the Mankin's score of osteoarthrotic knees appeared to be higher than the group receiving two 2% H2O2 injections without running load (p < 0.004, Kruskal‐Wallis H test). In the rats receiving a single 2% H2O2 injection with running load and a vitamin E‐enriched diet, the inhibitory effect of vitamin E on the development of osteoarthrosis was statistically significant compared to the regular diet group (p < 0.05, Wilcoxon rank test). Copyright © 1990 Orthopaedic Research Society

引用

页码：731 / 740

页数：10

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