RAPID AND REVERSIBLE CHANGES IN MYOSIN HEAVY-CHAIN EXPRESSION IN RESPONSE TO INCREASED NEUROMUSCULAR ACTIVITY OF RAT FAST-TWITCH MUSCLE

被引：46

作者：

KIRSCHBAUM, BJ

SCHNEIDER, S

IZUMO, S

MAHDAVI, V

NADALGINARD, B

PETTE, D

机构：

[1] UNIV CONSTANCE, FAK BIOL, POSTFACH 5560, W-7750 CONSTANCE, GERMANY

[2] CHILDRENS HOSP MED CTR, DEPT CARDIOL, MOLEC & CELLULAR CARDIOL LAB, BOSTON, MA 02115 USA

[3] HARVARD UNIV, SCH MED, DEPT PEDIAT, BOSTON, MA 02115 USA

来源：

FEBS LETTERS | 1990年 / 268卷 / 01期

关键词：

Chronic low-frequency stimulation; Fast-twitch muscle; Myosin heavy chain mRNA isoform;

D O I：

10.1016/0014-5793(90)80976-P

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chronic 10 Hz stimulation of rat fast-twitch muscle induced rapid and reversible changes in the tissue levels offast myosin heavy chain (HC) mRNA isoforms. These changes consisted of a rapid decrease in HCIIb mRNA and a progressive increase in HCIIa mRNA. After 15 days, the HCIIb mRNA normally amounting to approximately 80%, had decreased to less than 5% of the sum of the two HC mRNA isoforms. HCIIb mRNA was again detectable one day after cessation of stimulation and progressively increased at the expense of HCIIa mRNA with ongoing recovery. These results point to a down-regulation of the HCIIb gene by the applied stimulus pattern which, conversely, enhances the expression of the HCIIa gene. © 1990.

引用

页码：75 / 78

页数：4

共 16 条

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