HALOTHANE DOES NOT INHIBIT HUMAN NEUTROPHIL FUNCTION-INVITRO

Various indices of function of neutrophils from normal healthy volunteers have been examined after in vitro exposure to halothane. Random free movement on glass was unaffected, but random migration through millipore filters was slightly increased. There was no significant change in migra tion in response to casein chemotaxis. Phagocytosis, degranulation and the enhanced non mito chondrial respiration associated with phagocytosis were unaffected. Electron-microscopic appearance at 30 s after exposure to latex particles was normal in all respects. © 1979 Macmillan Journals Ltd.