ROLE OF N-METHYL-D-ASPARTATE AND OPIATE RECEPTORS IN NOCICEPTION DURING AND AFTER ISCHEMIA IN RATS

被引：47

作者：

SHER, GD ^{[1
]}

CARTMELL, SM ^{[1
]}

GELGOR, L ^{[1
]}

MITCHELL, D ^{[1
]}

机构：

[1] UNIV WITWATERSRAND,SCH MED,DEPT PHYSIOL,BRAIN FUNCT RES UNIT,YORK RD,JOHANNESBURG 2193,SOUTH AFRICA

来源：

PAIN | 1992年 / 49卷 / 02期

关键词：

N-METHYL-D-ASPARTATE RECEPTOR ANTAGONISTS; OPIATE AGONISTS; ISCHEMIA; POSTISCHEMIC HYPERALGESIA; REPERFUSION; ROTAROD;

D O I：

10.1016/0304-3959(92)90148-5

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

We have investigated the effects of systemic administration of two N-methyl-D-aspartate (NMDA) receptor antagonists and two opiate agonists on nociception during and after tail ischaemia in conscious rats. The two NMDA receptor antagoniStS, D-2-amino-5-phosphonovalerate (APV) and ketamine hydrochloride, did not alter tail flick latencies in rats not subjected to ischaemia but inhibited post-ischaemic hyperalgesia (PIH) in a dose-dependent manner. Neither of these agents impaired motor function of the rats, as assessed by rotarod performance, suggesting a purely sensory antinociceptive effect. The antinociceptive effect of APV during reperfusion following ischaemia was not antagonised by the mu-opiate receptor antagonist naloxone (1 mg/kg). The two opiate receptor agonists, morphine and pethidine, increased tail flick latencies in rats not subjected to ischaemia, inhibited PIH in a dose-dependent manner, and also caused significant motor malfunction, all in naloxone-reversible fashion. We conclude that the role of the NMDA receptor in mediating afferent nociceptive traffic is confined to its involvement in neuronal events mediating hyperalgesia.

引用

页码：241 / 248

页数：8

共 46 条

[1]

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[2]

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