STIMULATORY EFFECTS OF QUINPIROLE HYDROCHLORIDE, D2-DOPAMINE RECEPTOR AGONIST, AT LOW CONCENTRATIONS ON PROLACTIN-RELEASE IN FEMALE RATS INVITRO

被引：15

作者：

TAGAWA, R ^{[1
]}

TAKAHARA, J ^{[1
]}

SATO, M ^{[1
]}

NIIMI, M ^{[1
]}

MURAO, K ^{[1
]}

ISHIDA, T ^{[1
]}

机构：

[1] KAGAWA MED SCH,CENT LABS,MIKI 17501,KAGAWA,JAPAN

来源：

LIFE SCIENCES | 1992年 / 51卷 / 10期

关键词：

D O I：

10.1016/0024-3205(92)90481-4

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Dopamine (DA) has dual actions (inhibitory and stimulatory) in the regulation of prolactin (PRL) release, depending on its concentration. To investigate the stimulatory effects of DA, perifused rat anterior pituitary cells were exposed to the highly-specific DA D2 receptor agonist, quinpirole hydrochloride (LY). Very low concentrations of LY (10(-12)-10(-10)M) stimulated PRL release and potentiated thyrotropin-releasing hormone (TRH)-induced PRL release. Higher concentrations of LY did not stimulate. Pretreatment with pertussis toxin (30 ng/ml, 24 h) completely abolished these effects of LY. The D2 receptor antagonist, metocloprimide, also blocked the potentiation by LY of TRH-induced PRL release. These data indicate that very low concentrations of dopamine stimulate PRL release via an interaction with a D2 receptor connected to a pertussis toxin-sensitive G protein.

引用

页码：727 / 732

页数：6

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