INHIBITION OF RAPID POTASSIUM FLUX DURING CEREBRAL-ISCHEMIA INVIVO WITH AN EXCITATORY AMINO-ACID ANTAGONIST

被引：15

作者：

KATAYAMA, Y ^{[1
]}

TAMURA, T ^{[1
]}

BECKER, DP ^{[1
]}

TSUBOKAWA, T ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES, SCH MED, DIV NEUROSURG, LOS ANGELES, CA 90024 USA

来源：

BRAIN RESEARCH | 1991年 / 568卷 / 1-2期

关键词：

CEREBRAL ISCHEMIA; EXCITATORY AMINO ACID; KYNURENIC ACID; POTASSIUM ION; MICRODIALYSIS; SPREADING DEPRESSION;

D O I：

10.1016/0006-8993(91)91412-T

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous studies have demonstrated that microdialysis is capable of detecting an abrupt and massive increase in extracellular K+ concentration ([K+]e) and a concomitant increase in extracellular concentration of excitatory amino acids (EAAs) during cerebral ischemia in the rat hippocampus in vivo. Following in situ administration of kynurenic acid (KYN), a broad-spectrum antagonist of EAAs, through the dialysis probe (5-10 mM), a delay in reaching the maximum level of increased [K+]e was observed in a dose-dependent manner. The initial component of the rapid increase in [K+]e appears to be mediated by EAAs released from nerve terminals.

引用

页码：294 / 298

页数：5

共 33 条

[1] CORTICAL EVOKED-POTENTIAL AND EXTRACELLULAR K+ AND H+ AT CRITICAL LEVELS OF BRAIN ISCHEMIA [J].

ASTRUP, J ;

SYMON, L ;

BRANSTON, NM ;

LASSEN, NA .

STROKE, 1977, 8 (01) :51-57

[2]

BENVENISTE H, 1989, J CEREB BLOOD FLOW M, V9, pS46

[3] KINETICS OF EXTRACELLULAR POTASSIUM CHANGES DURING HYPOXIA AND ANOXIA IN CAT CEREBRAL-CORTEX [J].

BLANK, WF ;

KIRSHNER, HS .

BRAIN RESEARCH, 1977, 123 (01) :113-124

[4]

CHOI DW, 1988, J NEUROSCI, V8, P185

[5] CELLULAR-ORIGIN OF ISCHEMIA-INDUCED GLUTAMATE RELEASE FROM BRAIN-TISSUE INVIVO AND INVITRO [J].

DREJER, J ;

BENVENISTE, H ;

DIEMER, NH ;

SCHOUSBOE, A .

JOURNAL OF NEUROCHEMISTRY, 1985, 45 (01) :145-151

[6]

GANONG AH, 1986, J PHARMACOL EXP THER, V236, P293

[7] KYNURENIC ACID INHIBITS SYNAPTIC AND ACIDIC AMINO ACID-INDUCED RESPONSES IN THE RAT HIPPOCAMPUS AND SPINAL-CORD [J].

GANONG, AH ;

LANTHORN, TH ;

COTMAN, CW .

BRAIN RESEARCH, 1983, 273 (01) :170-174

[8] EFFECT OF ISCHEMIA ON THE INVIVO RELEASE OF STRIATAL DOPAMINE, GLUTAMATE, AND GAMMA-AMINOBUTYRIC ACID STUDIED BY INTRACEREBRAL MICRODIALYSIS [J].

GLOBUS, MYT ;

BUSTO, R ;

DIETRICH, WD ;

MARTINEZ, E ;

VALDES, I ;

GINSBERG, MD .

JOURNAL OF NEUROCHEMISTRY, 1988, 51 (05) :1455-1464

[9] KETAMINE BLOCKADE OF CORTICAL SPREADING DEPRESSION IN RATS [J].

GORELOVA, NA ;

KOROLEVA, VI ;

AMEMORI, T ;

PAVLIK, V ;

BURES, J .

ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1987, 66 (04) :440-447

[10] ISCHEMIA-INDUCED SHIFT OF INHIBITORY AND EXCITATORY AMINO-ACIDS FROM INTRACELLULAR TO EXTRACELLULAR COMPARTMENTS [J].

HAGBERG, H ;

LEHMANN, A ;

SANDBERG, M ;

NYSTROM, B ;

JACOBSON, I ;

HAMBERGER, A .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1985, 5 (03) :413-419

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