THE SYNTHESIS OF [C-14] PANTOPRAZOLE - SK-AND-F 96022Z - AN H+/K+ ATPASE INHIBITOR

Pantoprazole 1, SK&F 96022Z, an H+/K+ ATPase inhibitor has been prepared, radiolabelled with carbon-14, in two positions, for drug metabolism studies. [Benzimidazole 2-C-14]pantoprazole in 4 steps from potassium ethyl, [C-14]xanthate, and [pyridylmethyl-C-14]pantoprazole from cuprous [C-14]cyanide in 8 steps. The overall radiochemical yields of these syntheses were 37.9% and 5.2% respectively.