METABOLISM OF ALBENDAZOLE AND ALBENDAZOLE SULFOXIDE BY RUMINAL AND INTESTINAL FLUIDS OF SHEEP AND CATTLE

被引：63

作者：

LANUSSE, CE ^{[1
]}

NARE, B ^{[1
]}

GASCON, LH ^{[1
]}

PRICHARD, RK ^{[1
]}

机构：

[1] MCGILL UNIV,INST PARASITOL,MACDONALD CAMPUS,21111 LAKESHORE RD,ST ANNE BELLEVUE H9X 1C0,QUEBEC,CANADA

来源：

XENOBIOTICA | 1992年 / 22卷 / 04期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.3109/00498259209046653

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The metabolism of albendazole (ABZ), albendazole sulphoxide (ABZSO) and albendazole sulphone (ABZSO2) by ruminal, abomasal and ileal fluids of sheep and cattle was investigated under anaerobic conditions in vitro. 2. None of the compounds was metabolically changed by incubation with abomasal fluids of sheep and cattle. 3. ABZ and ABZSO were extensively metabolized by sheep and cattle ruminal and ileal fluids. ABZSO2 was unaffected by incubation with these gastrointestinal fluids. 4. The rate of ABZ oxidation into ABZSO was greater for cattle ruminal and ileal fluids than for sheep fluids. 5. ABZSO was reduced back to ABZ by ruminal and ileal fluids of both species. This reducing activity was significantly higher for both ruminal and ileal fluids of sheep compared with those of cattle.

引用

页码：419 / 426

页数：8

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