Endometrial stomal sarcoma with clonal chromosomal aberrations and mixed phenotype

被引：17

作者：

Fuzesi, L ^{[1
]}

Gunawan, B ^{[1
]}

Braun, S ^{[1
]}

Karl, MC ^{[1
]}

机构：

[1] ST ANTONIUS HOSP, DEPT GYNECOL, ESCHWEILER, GERMANY

来源：

CANCER GENETICS AND CYTOGENETICS | 1995年 / 84卷 / 01期

关键词：

D O I：

10.1016/0165-4608(95)00088-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report a case of a moderate-grade endometrial stromal sarcoma with the following chromosomal complement based on the evaluation of 43 metaphases: 47,XX,der(3)t(3;6)(q29;p21.1),der(6) t(3;6)(q21;q27), + 19. Immunohistochemically, the paraffin-embedded tumor tissue displayed positive vimentin reactivity and lack of cytokeratin expression, indicating a mesenchymal origin. Interestingly, the cultivated tumor cells revealed a co-expression of vimentin and different subtypes of cytokeratin. Therefore, the cytogenetically monoclonal tumor cells which showed co-expression of epithelial and mesenchymal phenotypes suggest that the endometrial stromal sarcoma can be interpreted as a monophasic variant of the malignant mixed Mullerian tumor.

引用

页码：85 / 88

页数：4

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