MAPPING OF ADENYLYL-CYCLASE GENES TYPE-I, TYPE-II, TYPE-III, TYPE-IV, TYPE-V AND TYPE-VI IN MOUSE

被引:25
作者
EDELHOFF, S
VILLACRES, EC
STORM, DR
DISTECHE, CM
机构
[1] UNIV WASHINGTON,SCH MED,DEPT PATHOL,SEATTLE,WA 98195
[2] UNIV WASHINGTON,SCH MED,DEPT PSYCHIAT & BEHAV SCI,SEATTLE,WA 98195
[3] UNIV WASHINGTON,SCH MED,DEPT PHARMACOL,SEATTLE,WA 98195
关键词
D O I
10.1007/BF00303253
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The adenylyl cyclases (AC) act as second messengers in regulatory processes in the central nervous system. They might be involved in the pathophysiology of diseases, but their biological function is unknown, except for AC type I, which has been implicated in learning and memory. We previously mapped the gene encoding AC I to human Chromosome (Chr) 7p12. In this study we report the mapping of the adenylyl cyclase, genes type I-VI to mouse chromosomes by fluorescence in situ hybridization (FISH): Adcyl to Chr 11A2, Adcy2 to 13Cl, Adcy3 to 12A-B, Adcy4 to 14D3, Adcy5 to 16B5, and Adcy6 to 15F. We also confirmed previously reported mapping results of the corresponding human loci ADCY2, ADCY3, ADCY5, and ADCY6 to human chromosomes and, in addition, determined the chromosomal location of ADCY4 to human Chr 14q11.2. The mapping data confirm known areas of conservation between mouse and human chromosomes.
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页码:111 / 113
页数:3
相关论文
共 19 条
[1]   IDENTIFICATION OF A SPECIALIZED ADENYLYL CYCLASE THAT MAY MEDIATE ODORANT DETECTION [J].
BAKALYAR, HA ;
REED, RR .
SCIENCE, 1990, 250 (4986) :1403-1406
[2]  
CALI JJ, 1994, J BIOL CHEM, V269, P12190
[3]   The regulatory diversity of the mammalian adenylyl cyclases [J].
Choi, Eui-Ju ;
Xia, Zhengui ;
Villacres, Enrique C. ;
Storm, Daniel R. .
CURRENT OPINION IN CELL BIOLOGY, 1993, 5 (02) :269-273
[4]   A GENETIC-LINKAGE MAP OF THE MOUSE - CURRENT APPLICATIONS AND FUTURE-PROSPECTS [J].
COPELAND, NG ;
JENKINS, NA ;
GILBERT, DJ ;
EPPIG, JT ;
MALTAIS, LJ ;
MILLER, JC ;
DIETRICH, WF ;
WEAVER, A ;
LINCOLN, SE ;
STEEN, RG ;
STEIN, LD ;
NADEAU, JH ;
LANDER, ES .
SCIENCE, 1993, 262 (5130) :57-66
[5]  
EDELHOFF S, 1994, ONCOGENE, V9, P665
[6]   MOLECULAR-CLONING AND CHARACTERIZATION OF A CA2+ CALMODULIN-INSENSITIVE ADENYLYL CYCLASE FROM RAT-BRAIN [J].
FEINSTEIN, PG ;
SCHRADER, KA ;
BAKALYAR, HA ;
TANG, WJ ;
KRUPINSKI, J ;
GILMAN, AG ;
REED, RR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (22) :10173-10177
[7]   DISTRIBUTION OF TYPE-II ADENYLYL-CYCLASE MESSENGER-RNA IN THE RAT-BRAIN [J].
FURUYAMA, T ;
INAGAKI, S ;
TAKAGI, H .
MOLECULAR BRAIN RESEARCH, 1993, 19 (1-2) :165-170
[8]   CLONING AND EXPRESSION OF A WIDELY DISTRIBUTED (TYPE-IV) ADENYLYL CYCLASE [J].
GAO, BN ;
GILMAN, AG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (22) :10178-10182
[9]  
Green MC., 1989, GENETIC VARIANTS STR, P12
[10]   CHROMOSOMAL MAPPING OF HUMAN ADENYLYL-CYCLASE GENES TYPE-III, TYPE-V AND TYPE-VI [J].
HABER, N ;
STENGEL, D ;
DEFER, N ;
ROECKEL, N ;
MATTEI, MG ;
HANOUNE, J .
HUMAN GENETICS, 1994, 94 (01) :69-73