ENHANCEMENT OF GASTROINTESTINAL ABSORPTION OF HYDROCHLOROTHIAZIDE BY PROPANTHELINE

被引：29

作者：

BEERMANN, B ^{[1
]}

GROSCHINSKYGRIND, M ^{[1
]}

机构：

[1] SERAFIMER HOSP,CLIN PHARMACOL LAB,S-11283 STOCKHOLM,SWEDEN

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1978年 / 13卷 / 05期

关键词：

Diuretic; drug interaction; gastrointestinal absorption; hydrochlorothiazide; propantheline;

D O I：

10.1007/BF00644613

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hydrochlorothiazide 75 mg was given twice p.o. to fasting subjects. In the second study they had been pretreated with propantheline 60 mg. Plasma and urine concentrations of hydrochlorothiazide were determined by GLC. Pretreatment with propantheline on average delayed the maximal plasma level of hct from 2.4 to 4.8 h (p<0.05); and the total urinary recovery of hydrochlorothiazide by 48 h was increased from 49.3 mg to 66.9 mg (p<0.005). It was concluded that propantheline increased substantially the absorption of the diuretic. © 1978 Springer-Verlag.

引用

页码：385 / 387

页数：3

共 7 条

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