INTERACTIONS BETWEEN TYPE-1 PLASMINOGEN-ACTIVATOR INHIBITOR, EXTRACELLULAR-MATRIX AND VITRONECTIN

被引：56

作者：

SEIFFERT, D ^{[1
]}

MIMURO, J ^{[1
]}

SCHLEEF, RR ^{[1
]}

LOSKUTOFF, DJ ^{[1
]}

机构：

[1] Scripps Res Inst, RES INST, COMM VASC BIOL, LA JOLLA, CA 92037 USA

来源：

CELL DIFFERENTIATION AND DEVELOPMENT | 1990年 / 32卷 / 03期

关键词：

PLASMINOGEN ACTIVATOR INHIBITOR; EXTRACELLULAR MATRIX; VITRONECTIN;

D O I：

10.1016/0922-3371(90)90041-T

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Regulation of plasminogen activation is a key process in controlling proteolytic events in the extracellular matrix (ECM) and this regulation is achieved through the action of specific plasminogen activator (PA) inhibitors (PAIs). Type I PAI (PAI-1) is the physiological inhibitor both of urinary-type PA (u-PA) and tissue-type PA (t-PA) Loskutoff et al., 1989) and is a major component of the ECM of cultured cells. This inhibitor may protect ECM constituents against cellular proteases and thus influence the cell migration and tissue destruction that occurs during development, inflammation and tumor metastasis. In this review, we discuss the properties of PAI-1 and the evidence that the binding of PAI-1 to ECM is mediated by serum-derived vitronectin (Vn).

引用

页码：287 / 292

页数：6

共 25 条

[1] GENERATION IN PLASMA OF A FAST-ACTING INHIBITOR OF PLASMINOGEN-ACTIVATOR IN RESPONSE TO ENDOTOXIN STIMULATION
COLUCCI, M
PARAMO, JA
COLLEN, D
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1985, 75 (03) : 818 - 824
[2] PLASMINOGEN ACTIVATORS, TISSUE DEGRADATION, AND CANCER
DANO, K
ANDREASEN, PA
GRONDAHLHANSEN, J
KRISTENSEN, P
NIELSEN, LS
SKRIVER, L
[J]. ADVANCES IN CANCER RESEARCH, 1985, 44 : 139 - 266
[3] DECLERCK PJ, 1988, J BIOL CHEM, V263, P15454
[4] EHRLICH HJ, 1990, J BIOL CHEM, V265, P13029
[5] PLASMINOGEN-ACTIVATOR INHIBITOR IS ASSOCIATED WITH THE EXTRACELLULAR-MATRIX OF CULTURED BOVINE SMOOTH-MUSCLE CELLS
KNUDSEN, BS
HARPEL, PC
NACHMAN, RL
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1987, 80 (04) : 1082 - 1089
[6] LAIHO M, 1987, J BIOL CHEM, V262, P17467
[7] LAMBERS JWJ, 1987, J BIOL CHEM, V262, P17492
[8] ASSOCIATION OF A PLASMINOGEN-ACTIVATOR INHIBITOR (PAI-1) WITH THE GROWTH SUBSTRATUM AND MEMBRANE OF HUMAN-ENDOTHELIAL CELLS
LEVIN, EG
SANTELL, L
[J]. JOURNAL OF CELL BIOLOGY, 1987, 105 (06) : 2543 - 2549
[9] LINDAHL TL, 1989, THROMB HAEMOSTASIS, V62, P748
[10] LOSKUTOFF DJ, 1989, PROG HEMOST THROMB, V9, P87

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