DECREASE IN SERUM RECEPTOR-REACTIVE SOMATOMEDIN IN DIABETES

被引：44

作者：

BAXTER, RC ^{[1
]}

BROWN, AS ^{[1
]}

TURTLE, JR ^{[1
]}

机构：

[1] UNIV SYDNEY,DEPT MED,SYDNEY 2006,NEW S WALES,AUSTRALIA

来源：

HORMONE AND METABOLIC RESEARCH | 1979年 / 11卷 / 03期

关键词：

D O I：

10.1055/s-0028-1092711

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Somatomedin in rat serum has been measured by a sensitive radioreceptor assay using 125I-labelled human somatomedin and human placental membrane. In rats made diabetic with streptozotocin, receptor-reactive somatomedin levels were decreased by up to 75%. The decrease followed the time course of increasing serum glucose and occurred to the same extent in rats aged between 4 and 40 weeks. Endogenous serum receptor-reactive somatomedin appeared exclusively in high molecular weight fractions on gel chromatography In diabetes the decreased somatomedin was due to a fall in this high molecular weight activity, but was not accompanied by a fall in somatomedin binding protein. These results suggest a role for insulin in maintaining serum somatomedin levels.

引用

页码：216 / 220

页数：5

共 24 条

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