D-PENICILLAMINE AND IMMUNE-COMPLEX DEPOSITION

被引：27

作者：

KIRBY, JD

DIEPPE, PA

HUSKISSON, EC

SMITH, B

机构：

[1] ST BARTHOLOMEWS HOSP,DEPT RHEUMATOL,LONDON EC1A 7BE,ENGLAND

[2] ST BARTHOLOMEWS HOSP,DEPT DERMATOL,LONDON EC1A 7BE,ENGLAND

[3] ST BARTHOLOMEWS HOSP,DEPT PATHOL,LONDON EC1A 7BE,ENGLAND

来源：

ANNALS OF THE RHEUMATIC DISEASES | 1979年 / 38卷 / 04期

关键词：

D O I：

10.1136/ard.38.4.344

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Dense, granular immunoglobulin deposits have been identified at the epidermo-dermal junction in 4 out of 10 patients who developed toxic reactions to D-penicillamine therapy for rheumatoid arthritis. Three of 4 patients developing a lupus-like syndrome while on penicillamine had similar findings on skin biopsy. Serum immunoglobulin and complement levels decreased significantly in patients treated with penicillamine. It is suggested that, in addition to penicillamine nephrectomy, other side effects of this drug may be related to widespread deposition of immune complexes.

引用

页码：344 / 346

页数：3

共 13 条

[1]

BACON PA, 1976, Q J MED, V45, P661

[2] EFFECT OF D-PENICILLAMINE ON SERUM IMMUNOGLOBULINS AND RHEUMATOID-FACTOR [J].