RELEASE OF SLOW-REACTING SUBSTANCE FROM ANAPHYLACTIC LUNG-TISSUE AND ITS MODIFICATION BY BETA-SYMPATHOMIMETICS

被引：10

作者：

FORSBERG, K ^{[1
]}

SORENBY, L ^{[1
]}

机构：

[1] AB DRACO, FAC, RES & DEV LABS, S-22101 LUND, SWEDEN

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY | 1979年 / 58卷 / 04期

关键词：

D O I：

10.1159/000232223

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Anaphylactic release of slow-reacting substance of anaphylaxis (SRS-A) from chopped guinea pig lung was studied. The antibodies mediating the anaphylactic reaction were classified as IgG antibodies by PCA technique. Isoprenaline was found to inhibit the release of SRS-A in the concentration range 10-8_10-6M, while the β2-selective agonist terbutaline showed inhibition in the concentration range 10-6_10-5 M. The β1-selective β-agonist tazolol was ineffective when tested in the concentration range 10-7_10-5 M. The rank order of inhibitory potency of the compounds on SRS-A release agree with that for histamine release. © 1979 S. Karger AG, Basel.

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页码：430 / 435

页数：6

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