ANALYSIS OF ANTIEPILEPTIC DRUGS IN HUMAN PLASMA USING MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY

被引：56

作者：

LEE, KJ ^{[1
]}

HEO, GS ^{[1
]}

KIM, NJ ^{[1
]}

MOON, DC ^{[1
]}

机构：

[1] CHUNGBUK NATL UNIV,COLL PHARM,CHONGJU 306763,SOUTH KOREA

来源：

JOURNAL OF CHROMATOGRAPHY | 1992年 / 608卷 / 1-2期

关键词：

D O I：

10.1016/0021-9673(92)87130-Z

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We describe a method for the simultaneous determination of antiepileptic drugs (ethosuccimide, phenytoin, primidone, phenobarbital, carbamazepine and valproic acid) by micellar electrokinetic capillary chromatography using sodium dodecyl sulphate as the micellar phase. Factors affecting the micellar electrokinetic separation were studied for the quantitative determination of these drugs in human plasma. The confirmation of the peaks and the specificity of the method were investigated by combining multiwavelength detection with micellar electrokinetic capillary chromatography.

引用

页码：243 / 250

页数：8

共 23 条

[1] DETERMINATION OF ANTIEPILEPTIC DRUGS [J].

BURKE, JT ;

THENOT, JP .

JOURNAL OF CHROMATOGRAPHY, 1985, 340 (MAY) :199-241

[2] CAPILLARY ELECTROPHORESIS ELECTROSPRAY IONIZATION-MASS SPECTROMETRY [J].

EDMONDS, CG ;

LOO, JA ;

BARINAGA, CJ ;

UDSETH, HR ;

SMITH, RD .

JOURNAL OF CHROMATOGRAPHY, 1989, 474 (01) :21-37

[3] LIQUID-CHROMATOGRAPHIC ANALYSIS OF ANTIEPILEPTIC DRUGS - AN OVERVIEW [J].

FAZIO, A ;

PERUCCA, E ;

PISANI, F .

JOURNAL OF LIQUID CHROMATOGRAPHY, 1990, 13 (19) :3711-3740

[4] APPLICATION OF A COMPUTER-ASSISTED HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC MULTIWAVELENGTH ULTRAVIOLET DETECTION SYSTEM TO SIMULTANEOUS TOXICOLOGICAL DRUG ANALYSES [J].

HAYASHIDA, M ;

NIHIRA, M ;

WATANABE, T ;

JINNO, K .

JOURNAL OF CHROMATOGRAPHY, 1990, 506 :133-143

[5] CAPILLARY ZONE ELECTROPHORESIS [J].

JORGENSON, JW ;

LUKACS, KD .

SCIENCE, 1983, 222 (4621) :266-272

[6] HPLC ANALYSIS OF ANTIEPILEPTIC DRUGS IN BLOOD-SAMPLES - MICROBORE SEPARATION OF 14 COMPOUNDS [J].

JUERGENS, U .

JOURNAL OF LIQUID CHROMATOGRAPHY, 1987, 10 (2-3) :507-532

[7] ANALYSIS OF ANTIEPILEPTIC DRUGS [J].

KAPETANOVIC, IM .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1990, 531 :421-457

[8] PHOTODIODE ARRAY DETECTION IN HIGH-PERFORMANCE CAPILLARY ELECTROPHORESIS [J].

KOBAYASHI, S ;

UEDA, T ;

KIKUMOTO, M .

JOURNAL OF CHROMATOGRAPHY, 1989, 480 :179-184

[9]

LEE ED, 1991, J CHROMATOGR, V545, P445

[10]

LEE KJ, 1992, IN PRESS CLIN CHEM

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