HYPOTHALAMIC-PITUITARY DYSFUNCTION FOLLOWING CNS PROPHYLAXIS IN ACUTE LYMPHOCYTIC-LEUKEMIA - CORRELATION WITH CT SCAN ABNORMALITIES

被引:38
作者
OLIFF, A [1 ]
BODE, U [1 ]
BERCU, BB [1 ]
DICHIRO, G [1 ]
GRAVES, V [1 ]
POPLACK, DG [1 ]
机构
[1] NCI,PEDIAT ONCOL BRANCH,BLDG 10,RM 3B 12,BETHESDA,MD 20205
来源
MEDICAL AND PEDIATRIC ONCOLOGY | 1979年 / 7卷 / 02期
关键词
acute lymphocytic leukemia; computed tomography; neuroendocrine function;
D O I
10.1002/mpo.2950070207
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
In an attempt to identify possible adverse effects of CNS prophylaxis (cranial radiation and intrathecal chemotherapy), we examined hypothalamic‐pituitary function in 23 patients with acute lymphocytic leukemia (ALL). Of 18 patients who had received both cranial radiation and intrathecal chemotherapy, nine had abnormally low growth hormone responses to insulin‐induced hypoglycemia (< 7.0 ng/ml). Seven of the nine patients with abnormally low growth hormone responses also mainfested ventricular dilatation on computed tomography (CT) brain scans, whereas only one of the nine patients with normal growth hormone responses demonstrated this CT scan finding (P = 0.015). The remaining patients, who had not received cranial radiation, had normal growth hormone responses and normal CT scans. There is a significant correlation between ventricular dilatation on CT and abnormally low peak growth hormone responses following CNS prophylaxis in ALL. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company
引用
收藏
页码:141 / 151
页数:11
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