BETA-CELL FUNCTION IN RELATION TO ISLET-CELL ANTIBODIES DURING THE 1ST 3 YR AFTER CLINICAL-DIAGNOSIS OF DIABETES IN TYPE-II DIABETIC-PATIENTS

被引:115
作者
GOTTSATER, A [1 ]
LANDINOLSSON, M [1 ]
FERNLUND, P [1 ]
LERNMARK, A [1 ]
SUNDKVIST, G [1 ]
机构
[1] LUND UNIV, MALMO GEN HOSP, DEPT CLIN CHEM, S-21401 MALMO, SWEDEN
关键词
D O I
10.2337/diacare.16.6.902
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE- To determine the effects of islet cell antibodies on beta-cell function during the first 3 yr after diagnosis in type II diabetic patients. RESEARCH DESIGN AND METhODS- Beta-cell function in type II diabetic patients with (n = 11, 50 +/- 5 yr of age) and without (n = 10, 52 +/- 4 yr of age) ICA was followed prospectively and compared with beta-cell function in type I adult diabetic patients (n = 17, 37 +/- 5 yr of age) and in healthy control subjects (n = 34, age 45 +/- 3 yr). Beta-cell function was evaluated as fasting C-peptide, 1 + 3 min C-peptide after intravenous glucose, and DELTA C-peptide after glucagon. RESULTS- Fasting C-peptide was equal in type II diabetic patients with ICA (0.30 +/- 0.03 nM) and type I diabetic patients (0.24 +/- 0.03 nM) at diagnosis, and decreased (P < 0.05) during 3 yr in these groups but not in type II diabetic patients without ICA. At diagnosis, type II diabetic patients with ICA showed a 1 + 3 min C-peptide (0.92 +/- 0.17 nM) lower (P < 0.001) than control subjects but higher (P < 0.05) than type I diabetic patients (0.53 +/- 0.11 nM). After 1 yr, 1 + 3 min C-peptide in type II diabetic patients with ICA had decreased (P < 0.05) to 0.18 +/- 0.11 nM and was equal to type I diabetic patients (0.38 +/- 0.10 nM). DELTA C-peptide after glucagon was equally impaired in type II diabetic patients with ICA (0. 38 +/- 0.06 nM) and type I diabetic patients (0.35 +/- 0.11 nM) at diagnosis. After 3 yr, type II diabetic patients with ICA had fasting C-peptide of 0.09 +/- 0.04 nM, 1 + 3 min C-peptide of 0.18 +/- 0.10 nM, and DELTA C-peptide after glucagon of 0.20 +/- 0.09 nM, values equal to type I diabetic patients but lower (P < 0.01) than in type II diabetic patients without ICA, whose values remained unchanged; fasting C-peptide of 0.97 +/- 0.17 nM, 1 + 3 min C-peptide of 2.31 +/- 0.50 nM, and DELTA C-peptide after glucagon of 1.76 +/- 0.28 nM. CONCLUSIONS- In patients considered Type II diabetic with ICA, beta-cell function progressively decreased after diagnosis, and after 3 yr was similar to type I diabetic patients, whereas beta-cell function in type II diabetic patients without ICA was unchanged.
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页码:902 / 910
页数:9
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共 53 条
  • [1] ASSAN R, 1985, LANCET, V1, P67
  • [2] PLASMA-C-PEPTIDE LEVELS AND CLINICAL REMISSIONS IN RECENT-ONSET TYPE-I DIABETIC-PATIENTS TREATED WITH CYCLOSPORINE-A AND INSULIN
    ASSAN, R
    FEUTREN, G
    SIRMAI, J
    LABORIE, C
    BOITARD, C
    VEXIAU, P
    DUROSTU, H
    RODIER, M
    FIGONI, M
    VAGUE, P
    HORS, J
    BACH, JF
    [J]. DIABETES, 1990, 39 (07) : 768 - 774
  • [3] ACUTE INSULIN-RESPONSE TO INTRAVENOUS GLUCOSE, GLUCAGON AND ARGININE IN SOME SUBJECTS AT RISK FOR TYPE-1 (INSULIN-DEPENDENT) DIABETES-MELLITUS
    BARDET, S
    ROHMER, V
    MAUGENDRE, D
    MARRE, M
    SEMANA, G
    LIMAL, JM
    ALLANNIC, H
    CHARBONNEL, B
    SAI, P
    [J]. DIABETOLOGIA, 1991, 34 (09) : 648 - 654
  • [4] CIRCULATING C-PEPTIDE IMMUNOREACTIVITY - STUDIES IN NORMALS AND DIABETIC PATIENTS
    BLOCK, MB
    STEINER, DF
    RUBENSTEIN, AH
    MAKO, ME
    [J]. DIABETES, 1972, 21 (10) : 1013 - +
  • [5] SERUM EXCHANGE AND USE OF DILUTIONS HAVE IMPROVED PRECISION OF MEASUREMENT OF ISLET CELL ANTIBODIES
    BONIFACIO, E
    LERNMARK, A
    DAWKINS, RL
    ARNAIZVILLENA, A
    BARBOSA, J
    BETTERLE, C
    BOEHM, B
    BOITARD, C
    BOTTAZZO, GF
    BRIGHT, GM
    CHAPEL, H
    DIMARIO, U
    EISENBARTH, GS
    ELLIOT, RB
    GERBITZ, K
    GLEICHMAN, H
    HARRISON, L
    HELMKE, K
    HULINSKY, I
    KOBAYASHI, T
    KUMAR, WJ
    LANDIN, M
    MOLENAAR, JL
    PALMER, JB
    PETER, JB
    REINAUER, KM
    SCOTT, RS
    SCOTTMORGAN, L
    SCHERBAUM, WA
    [J]. JOURNAL OF IMMUNOLOGICAL METHODS, 1988, 106 (01) : 83 - 88
  • [6] DECREASED HEPATIC INSULIN EXTRACTION IN SUBJECTS WITH MILD GLUCOSE-INTOLERANCE
    BONORA, E
    ZAVARONI, I
    COSCELLI, C
    BUTTURINI, U
    [J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 1983, 32 (05): : 438 - 446
  • [7] PROGRESSION TO TYPE-I DIABETES IN AUTOIMMUNE ENDOCRINE PATIENTS WITH ISLET CELL ANTIBODIES
    BOSI, E
    BECKER, F
    BONIFACIO, E
    WAGNER, R
    COLLINS, P
    GALE, EAM
    BOTTAZZO, GF
    [J]. DIABETES, 1991, 40 (08) : 977 - 984
  • [8] DIAGNOSIS OF PRE-TYPE-1 DIABETES
    CHASE, HP
    VOSS, MA
    BUTLERSIMON, N
    HOOPS, S
    OBRIEN, D
    DOBERSEN, MJ
    [J]. JOURNAL OF PEDIATRICS, 1987, 111 (06) : 807 - 812
  • [9] DAHLQUIST G, 1989, DIABETOLOGIA, V32, P2
  • [10] DCCT Res Grp, 1987, J CLIN ENDOCR METAB, V65, P30