ENZYMATIC-HYDROLYSIS OF HYDROPHILIC ESTERS BY LIPASES - CARBOXY DEBLOCKING OF PEPTIDES AND GLYCOPEPTIDES

被引：15

作者：

BRAUM, G ^{[1
]}

BRAUN, P ^{[1
]}

KOWALCZYK, D ^{[1
]}

KUNZ, H ^{[1
]}

机构：

[1] UNIV MAINZ,INST ORGAN CHEM,BECHER WEG 18-20,W-6500 MAINZ,GERMANY

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 19期

关键词：

ENZYMATIC PROTECTING GROUP TECHNIQUE; LIPASE-CATALYZED HYDROLYSIS; POLAR ESTERS; PEPTIDES; GLYCOPEPTIDES;

D O I：

10.1016/S0040-4039(00)93392-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The markedly hydrophilic 2-(N-morpholino)ethyl (MoEt) esters of protected peptides and glycopeptides are selectively and efficiently cleaved by lipases in water/acetone (10:1) at pH 7.

引用

页码：3111 / 3114

页数：4

共 22 条

[1] CARBOHYDRATE-SPECIFIC RECEPTORS OF THE LIVER
ASHWELL, G
HARFORD, J
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1982, 51 : 531 - 554
[2] BRAUN P, 1991, LIEBIGS ANN CHEM, P165
[3] BRAUN P, 1992, SYNLETT, P39
[4] BRAUN P, 1990, SYNLETT, P105
[5] HERSTELLUNG VON ALPHA-AMINOSAUREESTERN DURCH ALKOHOLYSE DER METHYLESTER
BRENNER, M
HUBER, W
[J]. HELVETICA CHIMICA ACTA, 1953, 36 (05) : 1109 - 1115
[6] BUCHHOLZ M, 1983, LIEBIGS ANN CHEM, P1859
[7] 9-FLUORENYLMETHOXYCARBONYL FUNCTION, A NEW BASE-SENSITIVE AMINO-PROTECTING GROUP
CARPINO, LA
HAN, GY
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1970, 92 (19) : 5748 - &
[8] GLASS JD, 1987, PEPTIDES, V9, P167
[9] HERRMANN P, 1987, WISS Z U HALLE, V36, P17
[10] HOECHST AG, 1991, Patent No. 41331397

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