SOME ASPECTS ON CHARACTERIZATION AND PROPERTIES OF CHARGED POLYSACCHARIDES - AN INVESTIGATION OF THE SYSTEM CARRAGEENAN AMITRIPTYLINE WATER WITH RELATION TO AMPHIPHILE ADSORPTION AND CHARGE-DENSITY

被引：33

作者：

CARAMLELHAM, N

SUNDELOF, LO

机构：

[1] Physical Pharmaceutical Chemistry, Uppsala University, BMC, S-751 23 Uppsala

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1995年 / 115卷 / 01期

关键词：

POLYSACCHARIDE; CARRAGEENAN; CHARGE DENSITY; AMITRIPTYLINE; ADSORPTION; PHASE SEPARATION; DIALYSIS EQUILIBRIUM;

D O I：

10.1016/0378-5173(94)00260-C

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The importance of a precise characterization of the polymeric material for pharmaceutical applications is exemplified by an adsorption study of the system carrageenan/amitriptyline/water performed by means of dialysis equilibrium measurements. It is shown how differences in charge density and chemical composition lead to a wide variation in adsorption and phase separation properties. Simple physico-chemical methods are suggested that provide a both rapid and precise characterization of polyelectrolyte materials. In particular, charge density, structure of the monomeric unit and accurate determination of the Donnan equilibrium are discussed.

引用

页码：103 / 111

页数：9

共 16 条

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ASPINALL OG, 1983, POLYSACCHARIDES, V2

[2]

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[3]

ASPINALL OG, 1982, POLYSACCHARIDES, V1

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