Evaluation of gastrointestinal behaviour in the rat of amphiphilic beta-cyclodextrin nanocapsules, loaded with indomethacin

被引：41

作者：

Skiba, M ^{[1
]}

Morvan, C ^{[1
]}

Duchene, D ^{[1
]}

Puisieux, F ^{[1
]}

Wouessidjewe, D ^{[1
]}

机构：

[1] UNIV PARIS 11,CTR PHARMACEUT,URA CNRS 1218,LAB PHYSICOCHIM PHARMACOTECH & BIOPHARM,F-92290 CHATENAY MALABRY,FRANCE

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1995年 / 126卷 / 1-2期

关键词：

amphiphilic cyclodextrins; nanocapsules; indomethacin; bioavailability; gastro-intestinal tolerance;

D O I：

10.1016/0378-5173(95)04121-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

With a view to investigating the role of encapsulation of indomethacin within modified beta-cyclodextrin (beta CD-C-6) nanocapsules, we prepared nanocapsules with indomethacin as a model drug. These particles had an average size of 194 nm and encapsulated approximately 99% of indomethacin. The encapsulation of indomethacin within orally administered beta CD-C-6 nanocapsules protected against both gastric and intestinal ulceration is compared with an oral administration of an aqueous solution of Indocid(R). The relative bioavailability was also increased by this encapsulation.

引用

页码：275 / 279

页数：5

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