TL-201 - QUANTITATION OF RIGHT VENTRICULAR HYPERTROPHY IN CHRONICALLY HYPOXIC RATS

被引：24

作者：

RABINOVITCH, M

FISHER, K

GAMBLE, W

REID, L

TREVES, S

机构：

[1] CHILDRENS HOSP MED CTR, DEPT CARDIOL, BOSTON, MA 02115 USA

[2] CHILDRENS HOSP MED CTR, DEPT PATHOL, BOSTON, MA 02115 USA

[3] CHILDRENS HOSP MED CTR, DEPT RADIOL, BOSTON, MA 02115 USA

[4] HARVARD UNIV, SCH MED, DEPT PEDIAT, BOSTON, MA 02115 USA

[5] HARVARD UNIV, SCH MED, DEPT PATHOL, BOSTON, MA 02115 USA

[6] HARVARD UNIV, SCH MED, DEPT RADIOL, BOSTON, MA 02115 USA

来源：

RADIOLOGY | 1979年 / 130卷 / 01期

关键词：

D O I：

10.1148/130.1.223

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Sprague Dawley rats were divided into 2 groups. Ten were kept in room air and 10 in hypobaric hypoxia (air at 380 mm Hg). After 2 weeks all were injected intravenously with 50 μCi of 201Tl and sacrificed. The right and left ventricles were separated, weighed, and measured for radioactivity in a gamma well counter. Left and right ventricular mass ratios (MR) correlated with 201Tl radioactivity ratios (TAR) in both control and hypoxic rats: r = 0.962 where MR = 0.863 TAR + 0.27. Myocardial 201Tl uptake reflects and quantitates normal and abnormal ventricular mass, the abnormal mass in this model consisting of right ventricular hypertrophy associated with hypoxic pulmonary hypertension.

引用

页码：223 / 225

页数：3

共 18 条

[1] TL-201 MYOCARDIAL PERFUSION IMAGING IN AORTIC-VALVE STENOSIS [J].