ACTION OF INTRA-CEREBRALLY INJECTED BETA-ENDORPHIN ON THE RATS CORE TEMPERATURE

被引:63
作者
MARTIN, GE [1 ]
BACINO, CB [1 ]
机构
[1] MERCK INST THERAPEUT RES, W POINT, PA 19486 USA
关键词
Indomethacin; Naloxone; Preoptic area; Prostaglandins; Rectal temperature; Serotonin; β-Endorphin;
D O I
10.1016/0014-2999(79)90285-1
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Microinjected directly into the preoptic anterior hypothalamus (POAH), β-endorphin (0.74-7.4 nmol) induced an increase in rectal temperature (RT) in the free-moving rat. Whereas the initial phase of the endorphin-induced rise in RT was partially attenuated by naloxone (5 or 20 mg/kg i.p.) or naltrexone (3 mg/kg i.p.), the late phase was completely blocked by the prostaglandin synthetase inhibitor, indomethacin (15 mg/kg i.p.). Pretreatment with a combination of indomethacin and naloxone resulted in an almost total block of the endorphin-induced increase in RT. Furthermore, the central serotonin antagonist, methergoline (1 mg/kg i.p.) antagonized the endorphin-evoked fever indicating serotonin may mediate the rise in RT. In contrast to the fever evoked in the POAH, β-endorphin (7.4 nmol), given into the lateral cerebral ventricle (LCV), elicited a marked drop in RT, catalepsy, and analgesia which were completely blocked by naloxone (5 mg/kg). Similar to morphine, β-endorphin elicited a naloxone-reversible hyperthemia when administered into the subarachnoid space surrounding the spinal cord. The similarities between gb-endorphin and morphine in their actions on RT as well as the possible role of serotonin or prostaglandins in β-endorphin's thermogenic action are discussed. © 1979.
引用
收藏
页码:227 / 236
页数:10
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