PROLIFERATION OF PEROXISOMES WITHOUT SIMULTANEOUS INDUCTION OF THE PEROXISOMAL FATTY-ACID BETA-OXIDATION

被引：22

作者：

BAUMGART, E

VOLKL, A

PILL, J

FAHIMI, HD

机构：

[1] UNIV HEIDELBERG,INST ANAT & CELL BIOL 2,DEPT ANAT & CELL BIOL 2,W-6900 HEIDELBERG,GERMANY

[2] BOEHRINGER MANNHEIM GMBH,MED RES DEPT,W-6800 MANNHEIM 31,GERMANY

来源：

FEBS LETTERS | 1990年 / 264卷 / 01期

关键词：

Hypolipidemic drug; Lipid; β-oxidation; Peroxisome proliferation;

D O I：

10.1016/0014-5793(90)80750-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Marked proliferation of rat hepatic peroxisomes is observed after treatment with a new potent hypolipidemic drug BM 15766, as well as after bezafibrate. Whereas the relative specific activity of the peroxisomal fatty acid βoxidation system is not affected by BM 15766 it is significantly increased after bezafibrate. This is also confirmed by immunoblot analysis of individual β-oxidation enzymes in highly purified peroxisome fractions. These observations suggest that peroxisome proliferation and the induction of the fatty acid β-oxidation are regulated separately. © 1990.

引用

页码：5 / 9

页数：5

共 17 条

[1] THE EFFECTS OF BM 15.766, AN INHIBITOR OF 7-DEHYDROCHOLESTEROL DELTA-7-REDUCTASE, ON CHOLESTEROL-BIOSYNTHESIS IN PRIMARY RAT HEPATOCYTES [J].