EXCITATORY AND INHIBITORY EFFECTS OF ADENOSINE ON THE NEUROTRANSMISSION IN THE HIPPOCAMPAL SLICES OF GUINEA-PIG

被引：61

作者：

NISHIMURA, S ^{[1
]}

MOHRI, M ^{[1
]}

OKADA, Y ^{[1
]}

MORI, M ^{[1
]}

机构：

[1] KOBE UNIV,SCH MED,DEPT PHYSIOL,7-5-1 KUSUNOKI CHO,KOBE 650,JAPAN

来源：

BRAIN RESEARCH | 1990年 / 525卷 / 01期

关键词：

Adenosine; Adenosine triphosphate; Excitation; Hippocampal slice; Inhibition; Neurotransmission; Postsynaptic potential;

D O I：

10.1016/0006-8993(90)91335-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Postsynaptic potentials (PSPs) were recorded from the granular cell layer of guinea pig hippocampal slices. Application of adenosine at a concentration of more than 10 μM in the incubation medium depressed the amplitude of the PSP, but adenosine at a concentration of 10 nM to 1 μM enhanced the amplitude of the PSP. The dose-response curve of the effect of adenosine showed an excitatory and inhibitory biphasic pattern. Adenosine analogues such as adenosine triphosphate (ATP), adenosine diphosphate (ADP) and nicotinamide adenine dinucleotide (NAD) showed similar biphasic effects, however β-γ-methyleneadenosinetriphosphate (β-γ-ATP), 5′-N-ethylcarboxamidoadenosine (NECA), N6-cyclohexyladenosine (CHA) and N6-R-phenylisopropyladenosibe (RPIA) revealed only inhibitory effects. © 1990.

引用

页码：165 / 169

页数：5

共 17 条

[1]

BURNSTOCK G, 1972, PHARMACOL REV, V24, P509

[2] NMDA RECEPTORS - THEIR ROLE IN LONG-TERM POTENTIATION [J].

COLLINGRIDGE, GL ;

BLISS, TVP .

TRENDS IN NEUROSCIENCES, 1987, 10 (07) :288-293

[3]

DALY JW, 1983, PHYSL PHARM ADENOSIN

[4] THE PHYSIOLOGICAL-ROLE OF ADENOSINE IN THE CENTRAL NERVOUS-SYSTEM [J].

DUNWIDDIE, TV .

INTERNATIONAL REVIEW OF NEUROBIOLOGY, 1985, 27 :63-139

[5] MICRO-IONTOPHORETIC STUDIES ON NEURONES IN CUNEATE NUCLEUS [J].

GALINDO, A ;

KRNJEVIC, K ;

SCHWARTZ, S .

JOURNAL OF PHYSIOLOGY-LONDON, 1967, 192 (02) :359-&

[6] CHARACTERIZATION OF INHIBITION MEDIATED BY ADENOSINE IN THE HIPPOCAMPUS OF THE RAT INVITRO [J].

GERBER, U ;

GREENE, RW ;

HAAS, HL ;

STEVENS, DR .

JOURNAL OF PHYSIOLOGY-LONDON, 1989, 417 :567-578

[7] THE CAPILLARY DILATOR SUBSTANCES IN DRY POWDERS OF SPINAL ROOTS - A POSSIBLE ROLE OF ADENOSINE TRIPHOSPHATE IN CHEMICAL TRANSMISSION FROM NERVE ENDINGS [J].

HOLTON, FA ;

HOLTON, P .

JOURNAL OF PHYSIOLOGY-LONDON, 1954, 126 (01) :124-140

[8] EFFECTS OF ATP ON PHOSPHATIDYLINOSITOL-PHOSPHOLIPASE-C AND INOSITOL 1-PHOSPHATE ACCUMULATION IN RAT-BRAIN SYNAPTOSOMES [J].

HUANG, HM ;

SUN, GY .

JOURNAL OF NEUROCHEMISTRY, 1988, 50 (02) :366-374

[9] ATP EXCITES A SUBPOPULATION OF RAT DORSAL HORN NEURONS [J].

JAHR, CE ;

JESSELL, TM .

NATURE, 1983, 304 (5928) :730-733

[10] PROTEIN-KINASE-C INHIBITORS ELIMINATE HIPPOCAMPAL LONG-TERM POTENTIATION [J].

LOVINGER, DM ;

WONG, KL ;

MURAKAMI, K ;

ROUTTENBERG, A .

BRAIN RESEARCH, 1987, 436 (01) :177-183

← 1 2 →