A FACILE CATALYTIC DEUTERATION OF UNSATURATED FATTY-ACIDS AND PHOSPHOLIPIDS

被引：3

作者：

AUGUST, A ^{[1
]}

DAO, CJ ^{[1
]}

JENSEN, D ^{[1
]}

ZHANG, Q ^{[1
]}

DEA, P ^{[1
]}

机构：

[1] CALIF STATE UNIV LOS ANGELES,DEPT CHEM & BIOCHEM,LOS ANGELES,CA 90032

来源：

MICROCHEMICAL JOURNAL | 1993年 / 47卷 / 1-2期

关键词：

D O I：

10.1006/mchj.1993.1036

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Selectively chain-deuterated fatty acids and phospholipids were synthesized by a modified method of the balloon technique used in the catalytic hydrogenation of unsaturated dicarboxylic acids. The modified method uses a specially designed twin-flask apparatus, with an attached inflatable bulb to control the pressure and act as a safety device. Deuterium gas was generated in situ from sodium borodeuteride and concentrated deuterium chloride in a compartment separate from the reaction mixture of lipid and catalyst. Two catalysts. platinum tetrachloride on activated charcoal and tris(triphenylphosphine)chlororhodium(I) were employed and compared. Quantitative yields of the deuterated products were obtained as analyzed by proton, deuterium. and phosphorus-31 NMR spectroscopy and by mass spectrometry. © 1993 Academic Press. All rights reserved.

引用

页码：224 / 229

页数：6

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