GLUTEN EXORPHIN-C - A NOVEL OPIOID PEPTIDE DERIVED FROM WHEAT GLUTEN

被引：67

作者：

FUKUDOME, S

YOSHIKAWA, M

机构：

[1] KYOTO UNIV,FAC AGR,DEPT FOOD SCI & TECHNOL,KYOTO 606,JAPAN

[2] NISSHIN FLOUR MILLING CO LTD,DEPT RES CONTROL,CHUO KU,TOKYO 103,JAPAN

来源：

FEBS LETTERS | 1993年 / 316卷 / 01期

关键词：

OPIOID PEPTIDE; WHEAT; GLUTEN; EXORPHIN;

D O I：

10.1016/0014-5793(93)81727-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

A novel opioid peptide, Tyr-Pro-Ile-Ser-Leu, was isolated from the pepsin-trypsin-chymotrypsin digest of wheat gluten. Its IC50 values were 40 muM and 13.5 muM in the GPI and MVD assays, respectively. This peptide was named gluten exorphin C. Gluten exorphin C had a structure quite different from any of the endogenous and exogenous opioid peptides ever reported in that the N-terminal Tyr was the only aromatic amino acid. The analogs containing Tyr-Pro-X-Ser-Leu were synthesized to study its structure-activity relationship. Peptides in which X was an aromatic amino acid or an aliphatic hydrophobic amino acid had opioid activity.

引用

页码：17 / 19

页数：3

共 10 条

[1]

NOVEL OPIOID-PEPTIDES DERIVED FROM MITOCHONDRIAL CYTOCHROME-B - CYTOCHROPHINS [J].