ADMINISTRATION OF LARGE DOSES OF VITAMIN-C DOES NOT DECREASE OXIDANT-INDUCED LUNG LIPID-PEROXIDATION CAUSED BY BACTERIAL-INDEPENDENT ACUTE PERITONITIS

被引:4
作者
DEMLING, R
IKEGAMI, K
PICARD, L
LALONDE, C
机构
[1] BETH ISRAEL HOSP, CTR LONGWOOD AREA TRAUMA, BOSTON, MA 02215 USA
[2] CHILDRENS HOSP, CTR LONGWOOD AREA TRAUMA, BOSTON, MA USA
[3] HARVARD UNIV, SCH MED, BOSTON, MA USA
关键词
D O I
10.1007/BF01560697
中图分类号
Q2 [细胞生物学];
学科分类号
071009 [细胞生物学]; 090102 [作物遗传育种];
摘要
Acute zymosan-induced peritonitis in rats produces lung inflammation and lipid peroxidation. The effect of this process on plasma and lung tissue ascorbic acid was determined, as was the effect of infusing 150 mg/kg of ascorbic acid immediately after zymosan on the degree of lung insult. Ascorbic acid levels were significantly decreased in plasma and lung tissue at 24 h after zymosan, and lung tissue conjugated diene and neutrophil content was also significantly increased. Vitamin C infusion increased postzymosan plasma levels by 50% over normal control levels. However, lung tissue ascorbic acid was still decreased, and no decrease in the lung injury process was noted. Added ascorbic acid also did not prevent a decrease in plasma vitamin E with the peritonitis. We conclude that the amount of ascorbic acid given in this study did not diminish the lung oxidant inflammatory changes. An insufficient dose or inadequate time for plasma ascorbic acid to equilibrate with the lung cytosol are possible explanations for the lack of attenuation of lung oxidant stress.
引用
收藏
页码:499 / 510
页数:12
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