HUMORAL IMMUNITY IN AGING

被引：89

作者：

PAGANELLI, R

SCALA, E

QUINTI, I

ANSOTEGUI, IJ

机构：

[1] Department of Clinical Immunology, “La Sapienza” University, Roma

[2] Cattedra di Immunologia Clinica E Allergologia, Università “La Sapienza”, Roma, 00185

来源：

AGING-CLINICAL AND EXPERIMENTAL RESEARCH | 1994年 / 6卷 / 03期

关键词：

AGING; B LYMPHOCYTES; CYTOKINES; IMMUNOGLOBULINS;

D O I：

10.1007/BF03324229

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The interactions between B and T lymphocytes, leading to the development of humoral responses, are reviewed with references to the changes occurring in aged people. Aging is perceived as a process of impairment of immune functions; it is known that T cells from aged subjects have a reduced ability to produce IL-2. However, other functions seem to be upregulated in elderly subjects; indeed, IL-1, IL-3, IL-4, IL-6 and TNF alpha production are increased both in aged mice and humans. These cytokines are known to control B cell differentiation, through isotype switch and Ig production. A significant increase in IgG subclasses and IgA is observed in sera of aged subjects. This contrasts with the significant decrease in circulating B lymphocytes. The impairment of primary responses to immunization, and other aspects of humoral immunity, including mucosal responses, autoantibody production and correlations with phenotypic markers of T and B cell subsets, are discussed.

引用

页码：143 / 150

页数：8

共 55 条

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