MOLECULAR CHARACTERISTICS OF URONIC-ACID-RICH PROTEIN, A STRONG INHIBITOR OF CALCIUM-OXALATE CRYSTALLIZATION INVITRO

被引：37

作者：

ATMANI, F

LACOUR, B

STRECKER, G

PARVY, P

DRUEKE, T

DAUDON, M

机构：

[1] LAB BIOCH,LILLE,FRANCE

[2] HOP NECKER ENFANTS MALAD,BIOCHIM LAB B,F-75730 PARIS 15,FRANCE

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 191卷 / 03期

关键词：

D O I：

10.1006/bbrc.1993.1338

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Uronic-acid-rich protein (UAP) is a new urinary macromolecule which strongly inhibits calcium oxalate crystal formation. It is a glycoprotein with a molecular weight of about 35, 000 Da, and its carbohydrate content is 8.5%. This inhibitor is composed of two polypeptidic chains crosslinked by chondroitin sulfate. It exhibits partial structural homology with α1- microglobulin. The inhibitory activity seems to be supported by peptidic chains as determined by enzymatic assay. © 1993 Academic Press, Inc.

引用

页码：1158 / 1165

页数：8

共 19 条

[1]

ATMANI F, 1992, IN PRESS UROL RES

[2] A MODIFIED URONIC ACID CARBAZOLE REACTION [J].