HEMOLYTIC-UREMIC SYNDROME IN CHILDHOOD - SURVEILLANCE AND CASE-CONTROL STUDIES IN ITALY

被引:43
作者
GIANVITI, A
ROSMINI, F
CAPRIOLI, A
CORONA, R
MATTEUCCI, MC
PRINCIPATO, F
LUZZI, I
RIZZONI, G
机构
[1] Division of Nephrology and Dialysis, Bambino Gesù Children's Research Hospital, Rome, I-00165
[2] Epidemiology and Biostatistic Laboratory, Istituto Superiore di Sanità, Rome
[3] Ultrastructure Laboratory, Istituto Superiore di Sanità, Rome
[4] Bacteriology and Mycology Laboratory, Istituto Superiore di Sanità, Rome
关键词
HEMOLYTIC-UREMIC SYNDROME; SURVEILLANCE STUDY; CASE-CONTROL STUDY; VEROCYTOTOXIN-PRODUCING; ESCHERICHIA COLI INFECTION;
D O I
10.1007/BF00869095
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Seventy-six cases of haemolytic-uraemic syndrome (HUS) were collected over a 4-year period during a surveillance and case-control study, The annual incidence of 0.2 per 100,000 children aged 0-14 years is lower than in other countries; 34% had no prodromal diarrhoea. Evidence for verocytotoxin-producing Escherichia coli (VTEC) infection was found in 72% of patients and 3% of controls; 88% of patients with bloody diarrhoea, 67% with non-bloody diarrhoea and 55% without diarrhoea were VTEC positive, Seventy-three percent of patients had creatinine clearance greater than or equal to 80 ml/min per 1.73 m(2), normal blood pressure, no proteinuria and haematuria <2+ after 1 year of follow-up, One patient died and none had non-renal sequelae, VTEC positivity was significantly correlated with a good outcome, while the absence of diarrhoea and a high total white blood cell count at onset were not predictors of a bad outcome. Household contacts of HUS patients had diarrhoea more frequently than those of the control group, supporting the hypothesis of person-to-person transmission of VTEC infection.
引用
收藏
页码:705 / 709
页数:5
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